3.4-seco-5α-cholestanedioic acid-(3.4) | 1177-98-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3.4-seco-5α-cholestanedioic acid-(3.4)
• 英文别名: 3.4-Seco-5α-cholestandisaeure-(3.4)
• CAS: 1177-98-6
• 化学式: C₂₇H₄₆O₄
• 分子量: 434.66
• InChiKey: CUKZMECJGGZUMT-FLCCAFLQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.87
• 重原子数：
  31.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3.4-seco-5α-cholestanedioic acid-(3.4) 在 乙酸酐 作用下， 生成 A-nor-5β-cholestan-3-one
  参考文献：
  名称：

  Auditory Model Enhances Relative-Timing Learning

  摘要：

  In recent experiments (Q. Lai, C. H. Shea, & M. Little, 2000; C. H. Shea, G. Wulf, J. Park, & B. Gaunt, 2001), auditory models were found to be effective in enhancing relative-timing performance and learning in constant practice conditions. In the present experiment, the authors examined (a) whether an auditory model also enhances relative-timing learning in blocked and random practice conditions and (b) whether experience with the auditory model enhances participants' ability to produce the response by using different effector sequences. Participants (N = 48) were randomly assigned to 1 of 4 acquisition conditions in which an auditory model was or was not present and the practice schedule was blocked or random. In the acquisition phase, all participants alternately pressed 2 keys on a keyboard in an attempt to match 5 goal intervals. In the auditory model conditions, a sequence of tones was played before each acquisition trial. The tones represented the correct timing sequence for that trial. One retention and 3 effector-transfer tests without feedback were administered about 24 hr after the completion of acquisition. The results indicated that the auditory model enhanced relative-timing performance and learning independently of practice schedule. In addition, the auditory model enhanced relative timing on the effector-transfer tests, but absolute-timing performance and learning were not affected by the auditory model. Thus, relative timing was found to be effector independent but absolute timing was not.

  DOI：

  10.1080/00222890209601948
• 作为产物：
  描述：

  胆甾-4-烯 在 硝酸 、 溶剂黄146 、 锌 作用下， 生成 3.4-seco-5α-cholestanedioic acid-(3.4)
  参考文献：
  名称：

  Windaus, Chemische Berichte, 1920, vol. 53, p. 488,491

  摘要：

  DOI：

文献信息

• SYNTHESIS AND CHARACTERIZATION OF PIPERAZINE-2,6-DIONES
  作者：Teresa Mancilla、Lourdes Canillo、Luis S. Zamudio-Rivera、Hiram I. Beltrán、Norberto Farán

  DOI：10.1080/00304940209355746

  日期：2002.2

  Our current interest in piperazine-2,6-dione 3 derivatives of a-amino acids prompted us to develop a methodology to obtain them from a-amino acid methyl ester hydrochlorides 2 and 2bromoacetamide. This paper describes a short, high yield synthesis and characterization of six new piperazine-2,6-diones 3b-g, as well as the known piperazine-2,6-dione 3a via 3+3 annulation. This method provides access to

  哌嗪二酮也称为二酮哌嗪，是最小的环肽，也是几种具有治疗特性的天然产品中的常见基序。研究表明，双二酮哌嗪对 Lewis 肺癌、肉瘤 180、L12 10 白血病、P388 白血病、B 16 骨髓瘤、恶性淋巴瘤、C-26 结肠癌、C-38 人结肠癌和乳腺癌具有抗肿瘤活性。 2-8也被用于临床试验联合治疗？进一步的研究旨在确定这些药物影响细胞生长的机制。'O'~哌嗪-2,6-二酮在第 3 位和第 4 位取代已显示出降血脂活性，3-取代的类似物更具活性，并阐明对小鼠正常和诱导的高脂血症均有效。14 制备哌嗪-2,6-二酮的可用方法很少。它们是由多肽、1sl6 亚氨基二乙酸和甲酸铵，17 通过还原 2,6dibenzyloxypyrazineI8 和用盐酸水解 4-benzyl-2,6-bishydroxyiminopiperazine 制备的。Iy 我们目前对哌嗪-2,6-dione 3 的兴趣α
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  作者：Christopher M. Long、Helen H. Suh、Petros Koutrakis

  DOI：10.1080/10473289.2000.10464154

  日期：2000.7

  A comprehensive indoor particle characterization study was conducted in nine Boston-area homes in 1998 in order to characterize sources of PM in indoor environments. State-of-the-art sampling methodologies were used to obtain continuous PM2.5 concentration and size distribution particulate data for both indoor and outdoor air. Study homes, five of which were sampled during two seasons, were monitored over week-long periods. Among other data collected during the extensive monitoring efforts were 24-hr elemental/organic carbon (EC/OC) particulate data as well as semi-continuous air exchange rates and time-activity information.This rich data set shows that indoor particle events tend to be brief, intermittent, and highly variable, thus requiring the use of continuous instrumentation for their characterization. In addition to dramatically increasing indoor PM2.5 concentrations, these data demonstrate that indoor particle events can significantly alter the size distribution and composition of indoor particles. Source event data demonstrate that the impacts of indoor activities are especially pronounced in the ultrafine (d(a) less than or equal to 0.1 mu m) and coarse (2.5 less than or equal to d(a) less than or equal to 10 mu m) modes. Among the sources of ultrafine particles characterized in this study are indoor ozone/terpene reactions. furthermore, EC/OC data suggest that organic carbon is a major constituent of particles emitted during indoor source events. Whether exposures to indoor-generated particles, particularly from large short-term peak events, may be associated with adverse health effects will become clearer when biological mechanisms are better known.
• 79. The action of selenium dioxide on sterols and bile acids. Part III. Cholesterol
  作者：O. Rosenheim、W. W. Starling

  DOI：10.1039/jr9370000377

  日期：——
• Butenandt et al., Chemische Berichte, 1936, vol. 69, p. 2779,2780
  作者：Butenandt et al.

  DOI：——

  日期：——
• Über Gallensäuren und verwandte Stoffe. 17. Mitteilung. Bildung von Lactonen aus Ketonen mit Benzopersäure
  作者：V. Burckhardt、T. Reichstein

  DOI：10.1002/hlca.19420250704

  日期：1942.12.1