μ-chlorobis(5,7-dichloro-8-hydroxyquinoline)bis(5,7-dichloro-8-oxyquinolinato)(ethanol)dinickel(II)-acetone (1/1) | 1357450-64-6

• 英文名称: μ-chlorobis(5,7-dichloro-8-hydroxyquinoline)bis(5,7-dichloro-8-oxyquinolinato)(ethanol)dinickel(II)-acetone (1/1)
• CAS: 1357450-64-6
• 化学式: C₃H₆O*C₃₈H₂₄Cl₁₀N₄Ni₂O₅
• 分子量: 1146.62
• InChiKey: YOMVDYAGGXLJIC-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  5,7-二氯-8-羟基喹啉 、 nickel(II) chloride hexahydrate 、 乙醇 、 丙酮 以 乙醇 、 丙酮 为溶剂， 以70%的产率得到μ-chlorobis(5,7-dichloro-8-hydroxyquinoline)bis(5,7-dichloro-8-oxyquinolinato)(ethanol)dinickel(II)-acetone (1/1)
  参考文献：
  名称：

  Synthesis, crystal structure, DNA interaction and cytotoxicity of a dinuclear nickel(II) complex with 5,7-dichloro-8-hydroxylquinoline

  摘要：

  A new nickel(II) complex with 5,7-dichloro-8-hydroxylquinoline (H-ClQ), [NiCl(ClQ)(H-ClQ)(mu-Cl)Ni(ClQ)(CH3CH2OH)(H-ClQ)]center dot CH3COCH3 (1), was synthesized and characterized. In solid state, 1 is consisted of a dinuclear nickel(II) complex and one acetone solvent molecule. Two Ni(II) atoms are chelated by two bidentate 5,7-dichloro-8-hydroxylquinolines and coordinated by one terminal Cl atom or ethanol ligand and one mu-Cl in a distorted octahedral coordination environment. The ESI-MS result shows that the mu-Cl bridge is easily broken in solution to give mononuclear species (omitted as ClQ-Ni complex). The IC50 values of 1 for the inhibition of the proliferation of BEL7404, SGC7901 and MCF-7 tumor cells are 13.0 +/- 2.1, 15.9 +/- 5.3, and 29.8 +/- 9.5 mu M, respectively, which exhibit significantly enhanced cytotoxicity comparing with free H-ClQ and NiCl2. The binding properties of ClQ-Ni complex to DNA were investigated by UV-Vis, fluorescence, CD spectroscopy, viscosity and agarose gel electrophoresis. The results indicate that intercalation is the most probable binding mode for ClQ-Ni complex to DNA. The ClQ-Ni complex exhibits potent TOPO I inhibition activity at 50 mu M. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.002