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    —— ethyl (4S)-6-[(4-acetylpiperazin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H24F2N4O4
    ethyl (4S)-6-[(4-acetylpiperazin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H25F3N4O3
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(2-fluorophenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-6-[[4-(4-acetylphenyl)piperazin-1-yl]methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H28F2N4O4
    ethyl (4R)-6-[[4-(4-acetylphenyl)piperazin-1-yl]methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H27F2N3O5
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-6-[(4-methylpiperazin-1-yl)methyl]-4-(4-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C19H25N5O5
    ethyl (4R)-6-[(4-methylpiperazin-1-yl)methyl]-4-(4-nitrophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H25F2N3O3
    ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H28F2N4O4
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C19H24F2N4O3
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(2,3-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H30F2N4O3
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(2,3-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H25F2N3O3
    ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-(azepan-1-ylmethyl)-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H25F2N3O3
    ethyl (4S)-6-(azepan-1-ylmethyl)-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-methylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H25F2N3O3
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-methylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-(piperidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C19H23F2N3O3
    ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-(piperidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C19H24F2N4O3
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H26F2N4O3
    ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-6-[(4-benzylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H29F2N3O3
    ethyl (4R)-6-[(4-benzylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-[(4-benzylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H29F2N3O3
    ethyl (4S)-6-[(4-benzylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(3-methylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H28F2N4O3
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(3-methylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2,3-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H30F2N4O3
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2,3-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H33N3O7
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-(thiomorpholin-4-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C18H21F2N3O3S
    ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-(thiomorpholin-4-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H28F2N4O4
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-(pyrrolidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C18H21F2N3O3
    ethyl (4R)-4-(3,4-difluorophenyl)-2-oxo-6-(pyrrolidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H32F2N4O3
    ethyl (4S)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-2-oxo-6-(pyrrolidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H27N3O5
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-2-oxo-6-(pyrrolidin-1-ylmethyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-2-oxo-6-[(4-prop-2-enylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C23H32N4O5
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-2-oxo-6-[(4-prop-2-enylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C21H30N4O5
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-methylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C25H28F2N4O4
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2,4-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H30F2N4O3
    ethyl (4R)-4-(3,4-difluorophenyl)-6-[[4-(2,4-dimethylphenyl)piperazin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H26F2N4O3
    ethyl (4S)-4-(3,4-difluorophenyl)-2-oxo-6-[(4-phenylpiperazin-1-yl)methyl]-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-(morpholin-4-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H27N3O6
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-(morpholin-4-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-6-[(4-carbamoylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H24F2N4O4
    ethyl (4R)-6-[(4-carbamoylpiperidin-1-yl)methyl]-4-(3,4-difluorophenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C23H23F2N3O3
    ethyl (4R)-4-(3,4-difluorophenyl)-6-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-(azepan-1-ylmethyl)-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H31N3O5
    ethyl (4S)-6-(azepan-1-ylmethyl)-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-difluorophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C21H25F2N3O5
    ethyl (4R)-4-(3,4-difluorophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-(morpholin-4-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C20H27N3O6
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-(morpholin-4-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C23H31N3O7
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-ylmethyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H27F2N3O5
    ethyl (4S)-4-(3,4-difluorophenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C23H32N4O7
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperazin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[[(3S)-3-ethoxycarbonylpiperidin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H33N3O7
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[[(3S)-3-ethoxycarbonylpiperidin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-[(4-acetylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H30N4O6
    ethyl (4S)-6-[(4-acetylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (3S)-1-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate —— C20H21ClN4O2
    ethyl (3S)-1-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-methylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H31N3O5
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-methylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H38N4O5
    ethyl (4R)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C22H32N4O5
    ethyl (4R)-4-(3,4-dimethoxyphenyl)-6-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C26H38N4O5
    ethyl (4S)-6-[(4-cyclohexylpiperazin-1-yl)methyl]-4-(3,4-dimethoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H33N3O7
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[(4-ethoxycarbonylpiperidin-1-yl)methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[[(3R)-3-ethoxycarbonylpiperidin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate —— C24H33N3O7
    ethyl (4S)-4-(3,4-dimethoxyphenyl)-6-[[(3R)-3-ethoxycarbonylpiperidin-1-yl]methyl]-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
    —— ethyl (3R)-1-[2-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate —— C22H26N4O4
    ethyl (3R)-1-[2-(3,4-dimethoxyphenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate
    —— ethyl (3S)-1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate —— C20H21FN4O2
    ethyl (3S)-1-[2-(4-fluorophenyl)pyrazolo[1,5-a]pyrazin-4-yl]piperidine-3-carboxylate