nucleotide diphosphatase | 9032-64-8

• 分子结构分类: 水解酶 - 作用于酸酐 - 在含磷酸酐中
• 英文名称: nucleotide diphosphatase
• 英文别名: ENPP1 (gene name)；nucleotide pyrophosphatase；nucleotide-sugar pyrophosphatase；nucleoside-triphosphate diphosphatase；snake venom nucleotide pyrophosphatase
• CAS: 9032-64-8

反应信息

• 作为试剂：
  描述：

  Adenosine diphospho-5-beta-ethyl-4-methylthiazole-2-carboxylic acid 在 nucleotide diphosphatase 、 thiamine phosphate synthase magnesium chloride 、 hydroxymethyl pyrimidine pyrophosphate 作用下， 以 水 为溶剂， 反应 4.0h， 生成 醌肟腙
  参考文献：
  名称：

  Thiamin Biosynthesis in Eukaryotes:  Characterization of the Enzyme-Bound Product of Thiazole Synthase from Saccharomyces cerevisiae and Its Implications in Thiazole Biosynthesis

  摘要：

  The biosynthesis of thiamin pyrophosphate in eukaryotes is different from the prokaryotic biosynthesis and is poorly understood to date. Only one thiazole biosynthetic gene has been identified (Thi4 in Saccharomyces cerevisiae). Here we report the identification and characterization of a Thi4-bound metabolite that consists of the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid. The unexpected structure of this compound yields the first insights into the mechanism of thiamin thiazole biosynthesis in eukaryotes.

  DOI：

  10.1021/ja061413o