cinchona alkaloid-derived thiourea

• 英文名称: cinchona alkaloid-derived thiourea

反应信息

• 作为试剂：
  描述：

  (E)-1-(furan-2-yl)-3-(4-methoxyphenyl)prop-2-en-1-one 、 氰乙酸乙酯 在 cinchona alkaloid-derived thiourea 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 ethyl 2-cyano-5-(furan-2-yl)-3-(4-methoxyphenyl)-5-oxo-pentanoate 、 ethyl 2-cyano-5-(furan-2-yl)-3-(4-methoxyphenyl)-5-oxo-pentanoate 、 ethyl 2-cyano-5-(furan-2-yl)-3-(4-methoxyphenyl)-5-oxo-pentanoate 、 ethyl 2-cyano-5-(furan-2-yl)-3-(4-methoxyphenyl)-5-oxo-pentanoate
  参考文献：
  名称：

  Highly enantioselective Michael additions of α-cyanoacetate with chalcones catalyzed by bifunctional cinchona-derived thiourea organocatalyst

  摘要：

  The conjugate addition of ethyl alpha-cyanoacetate with chalcones has been developed. In the presence of cinchona alkaloid-derived thiourea organocatalyst 1i (10 mol %), ethyl alpha-cyanoacetate could react with various chalcones to afford Michael adducts with high yields (80-92%) and enantioselectivities (83-95% ee). (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2007.02.016