chloro(N(4)-p-tolyl-2-acetylpyridine-thiosemicarbazonato)copper(II) | 949156-53-0

• 英文名称: chloro(N(4)-p-tolyl-2-acetylpyridine-thiosemicarbazonato)copper(II)
• 英文别名: [Cu(2Ac4pT)Cl]
• CAS: 949156-53-0
• 化学式: C₁₅H₁₅ClCuN₄S
• 分子量: 382.376
• InChiKey: HAGQQNHOTLPMRB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-(1-(pyridin-2-yl)ethylidene)-N-(4'-tolyl)hydrazinecarbothioamide 、 copper(II) choride dihydrate 以 乙醇 为溶剂， 以87%的产率得到chloro(N(4)-p-tolyl-2-acetylpyridine-thiosemicarbazonato)copper(II)
  参考文献：
  名称：

  Coordination to copper(II) strongly enhances the in vitro antimicrobial activity of pyridine-derived N(4)-tolyl thiosemicarbazones

  摘要：

  Five copper(II) complexes with N(4)-ortho, N(4)-meta and N(4)-para-tolyl thiosemicarbazones derived from 2-formyl and 2-acetylpyridine were obtained and thoroughly characterized. The crystal structure of N(4)-meta-tolyl-2-acetylpyridine thiosemicarbazone (H2Ac4mT) was determined, as well as that of its copper(II) complex [Cu(2Ac4mT)Cl], which contains an anionic ligand and a chloride in the coordination sphere of the metal. The in vitro antimicrobial activities of all thiosemicarbazones and their copper(II) complexes were tested against Salmonella typhinturium and Candida albicans. Upon coordination a substantial decrease in the minimum inhibitory concentration, from 225 to 1478 mu mol L-1 for the thiosernicarbazones to 5-30 mu mol L-1 for the complexes was observe against the growth of Salmonella typhimurium and from 0.7-26 to 0.3-7 mu mol L-1 against the growth of C albicans, suggesting that complexation to copper(II) could be an interesting strategy of dose reduction. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.03.002