1-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)piperidine-3-carboxamide | 97786-64-6

• 英文名称: 1-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)piperidine-3-carboxamide
• 英文别名: 1-(2-((2,6-dimethylphenyl)amino)-2-oxyethyl)piperidine-3-carboxamide；1-[2-(2,6-Dimethylanilino)-2-oxoethyl]piperidine-3-carboxamide
• CAS: 97786-64-6
• 化学式: C₁₆H₂₃N₃O₂
• 分子量: 289.378
• InChiKey: OKGYPPPQGSUQAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Charged ion channel blockers and methods for use
  申请人：Nocion Therapeutics, Inc.

  公开号：US10968179B2

  公开（公告）日：2021-04-06

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.

  本发明提供了式（I）化合物或其药学上可接受的盐类： 本发明的化合物、组合物、方法和试剂盒可用于治疗疼痛、瘙痒和神经源性炎症。
• CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE
  申请人：Nocion Therapeutics, Inc.

  公开号：EP3938345A1

  公开（公告）日：2022-01-19
• Charged Ion Channel Blockers and Methods for Use
  申请人：Nocion Therapeutics, Inc.

  公开号：US20200290953A1

  公开（公告）日：2020-09-17

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.
• [EN] CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE<br/>[FR] BLOQUEURS DE CANAUX IONIQUES CHARGÉS ET PROCÉDÉS D'UTILISATION
  申请人：NOCION THERAPEUTICS INC

  公开号：WO2020185830A1

  公开（公告）日：2020-09-17

  The invention provides compounds of Formula (I), or pharmaceutically acceptable salts thereof: (I) The compounds, compositions, methods and kits of the invention are useful for the treatment of pain, itch, and neurogenic inflammation.