Hexacarbonyl{3-(1-fluoro-1-methylethyl)-6,8-difluoro-4-(N-Boc-methylaminoethynyl)chromane}dicobalt | 1412443-54-9

• 英文名称: Hexacarbonyl{3-(1-fluoro-1-methylethyl)-6,8-difluoro-4-(N-Boc-methylaminoethynyl)chromane}dicobalt
• CAS: 1412443-54-9
• 化学式: C₂₆H₂₄Co₂F₃NO₉
• 分子量: 669.459
• InChiKey: FUVMXPGAKAKRMN-FAOHYDRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  Hexacarbonyl{3-(1-fluoro-1-methylethyl)-6,8-difluoro-4-(N-Boc-methylaminoethynyl)chromane}dicobalt 在 硝酸铈(3+)铵 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以52%的产率得到3-(1-fluoro-1-methylethyl)-6,8-difluoro-4-(N-Boc-methylaminoethynyl)chromane
  参考文献：
  名称：

  A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines

  摘要：

  The reaction of N-Boc-protected propargylamine with salicylaldehyde derivatives and their subsequent Nicholas cyclisation reaction to provide a range of novel benzopyrans is reported. The cyclisation reactions proceeded with excellent levels of diastereoselectivity to afford compounds with cis-relative stereochemistry. As far as we are able to ascertain these are the first reported examples of Nicholas cyclisation reactions of propargyl alcohols that bear a terminal alkynyl N-protected amino motif. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.087
• 作为产物：
  描述：

  hexacarbonyl[1-{3,5-difluoro-2-[(3-methylbut-2-en-1-yl)oxy]phenyl}-3-N-Boc-methylaminoprop-2-yn-ol]dicobalt 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以71%的产率得到Hexacarbonyl{3-(1-fluoro-1-methylethyl)-6,8-difluoro-4-(N-Boc-methylaminoethynyl)chromane}dicobalt
  参考文献：
  名称：

  A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines

  摘要：

  The reaction of N-Boc-protected propargylamine with salicylaldehyde derivatives and their subsequent Nicholas cyclisation reaction to provide a range of novel benzopyrans is reported. The cyclisation reactions proceeded with excellent levels of diastereoselectivity to afford compounds with cis-relative stereochemistry. As far as we are able to ascertain these are the first reported examples of Nicholas cyclisation reactions of propargyl alcohols that bear a terminal alkynyl N-protected amino motif. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.087