(2,4,6-triisopropylphenyl-SO2NC6H4(CH2NHSO2-2,4,6-triisopropylphenyl)2)RhCl(triphenylphosphine)2 | 1192062-06-8

• 英文名称: (2,4,6-triisopropylphenyl-SO2NC6H4(CH2NHSO2-2,4,6-triisopropylphenyl)2)RhCl(triphenylphosphine)2
• CAS: 1192062-06-8
• 化学式: C₈₉H₁₀₉ClN₃O₆P₂RhS₃
• 分子量: 1613.36
• InChiKey: XSYDCVPATLKDLG-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  丁炔二醇 、 (2,4,6-triisopropylphenyl-SO2NC6H4(CH2NHSO2-2,4,6-triisopropylphenyl)2)RhCl(triphenylphosphine)2 、 三苯基膦 在 tetrabutylammonium tetrafluoroborate 作用下， 以 二氯甲烷 为溶剂， 生成 Wilkinson's catalyst
  参考文献：
  名称：

  Rates and Mechanism of Rhodium-Catalyzed [2+2+2] Cycloaddition of Bisalkynes and a Monoalkyne

  摘要：

  The mechanism of RhCl(PPh3)(3)-catalyzed [2+2+2] cycloaddition of alkynes is investigated in the case of the reaction of symmetrical diynes 1a and 1b with the monoalkyne 3 (HOCH2-C C-CH2OH), leading to highly substituted benzene derivatives in dichloromethane at 25 degrees C. The two main steps of the catalytic cycle are characterized. The intermediate rhodacyclopentadiene Rh-III complexes 2a and 2b (formed by oxidative coupling after the coordination of the diynes 1a and 1b to RhCl(PPh3)(2)) are characterized by cyclic voltammetry, conductivity measurements, P-31 NMR, and ESI-MS. The formation of complexes 2a and 2b (step A) and their further reactions with the monoalkyne 3, which deliver RhCl(PPh3)(3) and the final product (step B), are followed by means of electrochemical techniques that deliver kinetic data for the two successive separately investigated steps. From the relative values of the half-reaction times of step A (t(A1/2) = 650 and 75 s for 1a and 1b, respectively) and step (t(B1/2) = 130 and 680 s for 2a and 2b, respectively) determined under stoichiometric conditions, it emerges that step A (coordination of the two C C bonds of 1, followed by oxidative coupling) is rate-determining in the reaction involving 2a, whereas step B (reaction of the intermediate complexes 2 with the monoalkyne 3) is rate-determining in the reaction involving 1b. Kinetic data for the catalytic cycle of a RhCl(PPh3)(3)-catalyzed [2+2+2] cycloaddition of alkynes are thus presented for the first time.

  DOI：

  10.1021/om900544u
• 作为产物：
  描述：

  Wilkinson's catalyst 、 1,6,11-tris[(2,4,6-triisopropylphenyl) sulfonamide]-1,6,11-triazaundeca-3,8-diyne 以 二氯甲烷 为溶剂， 以87%的产率得到(2,4,6-triisopropylphenyl-SO2NC6H4(CH2NHSO2-2,4,6-triisopropylphenyl)2)RhCl(triphenylphosphine)2
  参考文献：
  名称：

  Rates and Mechanism of Rhodium-Catalyzed [2+2+2] Cycloaddition of Bisalkynes and a Monoalkyne

  摘要：

  The mechanism of RhCl(PPh3)(3)-catalyzed [2+2+2] cycloaddition of alkynes is investigated in the case of the reaction of symmetrical diynes 1a and 1b with the monoalkyne 3 (HOCH2-C C-CH2OH), leading to highly substituted benzene derivatives in dichloromethane at 25 degrees C. The two main steps of the catalytic cycle are characterized. The intermediate rhodacyclopentadiene Rh-III complexes 2a and 2b (formed by oxidative coupling after the coordination of the diynes 1a and 1b to RhCl(PPh3)(2)) are characterized by cyclic voltammetry, conductivity measurements, P-31 NMR, and ESI-MS. The formation of complexes 2a and 2b (step A) and their further reactions with the monoalkyne 3, which deliver RhCl(PPh3)(3) and the final product (step B), are followed by means of electrochemical techniques that deliver kinetic data for the two successive separately investigated steps. From the relative values of the half-reaction times of step A (t(A1/2) = 650 and 75 s for 1a and 1b, respectively) and step (t(B1/2) = 130 and 680 s for 2a and 2b, respectively) determined under stoichiometric conditions, it emerges that step A (coordination of the two C C bonds of 1, followed by oxidative coupling) is rate-determining in the reaction involving 2a, whereas step B (reaction of the intermediate complexes 2 with the monoalkyne 3) is rate-determining in the reaction involving 1b. Kinetic data for the catalytic cycle of a RhCl(PPh3)(3)-catalyzed [2+2+2] cycloaddition of alkynes are thus presented for the first time.

  DOI：

  10.1021/om900544u