N-(2,6-dimethyl-3-nitro-phenyl)-2-(4-methyl-[1,4]diazepan-1-yl)-acetamide | 848441-73-6

• 英文名称: N-(2,6-dimethyl-3-nitro-phenyl)-2-(4-methyl-[1,4]diazepan-1-yl)-acetamide
• 英文别名: N-(2,6-dimethyl-3-nitrophenyl)-2-(4-methyl-1,4-diazepan-1-yl)acetamide
• CAS: 848441-73-6
• 化学式: C₁₆H₂₄N₄O₃
• 分子量: 320.392
• InChiKey: CCIVYJXOEMKKFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  81.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION<br/>[FR] ACETANILIDES ET BENZAMIDES SUBSTITUES UTILISES DANS LE TRAITEMENT DE L'ASTHME ET DES INFLAMMATIONS PULMONAIRES
  申请人：CORUS PHARMA

  公开号：WO2005025498A2

  公开（公告）日：2005-03-24

  Substituted acetanilide or benzamide compositions or formulations for delivery by aerosolization are described. The formulation contains an efficacious amount of acetanilide or benzamide compound able to inhibit inflammation in asthmatic lungs. Compounds of the invention are formulated in 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0. The method for treatment of respiratory tract inflammation by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by nebulization or dry powder inhaler.