d3-5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide | 929221-82-9

• 英文名称: d3-5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide
• 英文别名: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4-(trideuteriomethyl)pyrazole-3-carboxamide
• CAS: 929221-82-9
• 化学式: C₂₂H₂₁Cl₃N₄O
• 分子量: 466.77
• InChiKey: JZCPYUJPEARBJL-FIBGUPNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PREPARATION AND UTILITY OF SUBSTITUTED PYRAZOLE COMPOUNDS WITH CANNABINOID RECEPTOR ACTIVITY
  申请人：GANT G. Thomas

  公开号：US20070287734A1

  公开（公告）日：2007-12-13

  The present disclosure is directed to modulators of CB-1 type receptors and pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and the medical use of such compounds for the treatment and/or management of the severity and duration of obesity, metabolic syndrome, dyslipidemia, glucose imbalance, the inability to maintain weight loss, insulin resistance, a cardiovascular disorder, memory loss, drug dependence, a depressive disorder, a panic disorder, an obsessive-compulsive disorder, anxiety, post-traumatic stress syndrome, and any other condition in which it is beneficial to inhibit, inversely agonize or modulate a cannabinoid receptor are described.

  本披露涉及CB-1型受体的调节剂及其药用盐和前药，其化学合成，以及这些化合物的医学用途，用于治疗和/或管理肥胖、代谢综合征、血脂异常、葡萄糖失衡、无法维持体重减轻、胰岛素抵抗、心血管疾病、记忆丧失、药物依赖、抑郁症、恐慌症、强迫症、焦虑、创伤后应激综合征以及其他有益于抑制、反向激动或调节大麻素受体的情况。