1-[1-(4-oxo-4-p-tolyl-butyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one | 2318-35-6

• 英文名称: 1-[1-(4-oxo-4-p-tolyl-butyl)-piperidin-4-yl]-1,3-dihydro-benzoimidazol-2-one
• 英文别名: 3-[1-[4-(4-methylphenyl)-4-oxobutyl]piperidin-4-yl]-1H-benzimidazol-2-one
• CAS: 2318-35-6
• 化学式: C₂₃H₂₇N₃O₂
• 分子量: 377.486
• InChiKey: UUTBDJSCJYWSJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL ALLOSTERIC INHIBITORS OF THYMIDYLATE SYNTHASE
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INCORPORATED

  公开号：US20160067240A1

  公开（公告）日：2016-03-10

  The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g., radiation therapy and/or other chemotherapeutic agents that are administered to a subject having a tumor, cancer or neoplasia).
• Methods and Compositions for Treating HIV Infection
  申请人：Vanderbilt University

  公开号：US20160296506A1

  公开（公告）日：2016-10-13

  Disclosed are methods of treating HIV infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• METHODS AND COMPOSITIONS FOR TREATING CANCER
  申请人：Globavir BioSciences, Inc.

  公开号：US20160361298A1

  公开（公告）日：2016-12-15

  Described are compositions and methods for treating cancer. Some methods comprise the administration of an effective amount of at least one inhibitor of tryptophan 2,3-dioxygenase (TDO) and/or indoleamine 2,3-dioxygenase (IDO), optionally combined with one or more additional anti-cancer agents.
• METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS
  申请人：Vanderbilt University

  公开号：US20170319611A1

  公开（公告）日：2017-11-09

  Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase D inhibitors and/or Akt therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US9453017B2
  申请人：——

  公开号：US9453017B2

  公开（公告）日：2016-09-27