2-(3,5-dichlorophenylamino)-1-{(R)-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]pyrrolidin-1-yl}ethanone | 1374239-61-8

• 英文名称: 2-(3,5-dichlorophenylamino)-1-{(R)-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]pyrrolidin-1-yl}ethanone
• 英文别名: 2-(3,5-dichloroanilino)-1-[(3R)-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]pyrrolidin-1-yl]ethanone
• CAS: 1374239-61-8
• 化学式: C₁₉H₂₀Cl₂N₆O
• 分子量: 419.313
• InChiKey: CXYAJJVXBQENNP-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HETEROCYCLIC TYROSINE KINASE INHIBITORS
  申请人：Biogen MA Inc.

  公开号：US20170027956A1

  公开（公告）日：2017-02-02

  The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.
• US9273028B2
  申请人：——

  公开号：US9273028B2

  公开（公告）日：2016-03-01
• [EN] HETEROCYCLIC TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE HÉTÉROCYCLIQUES
  申请人：BIOGEN IDEC INC

  公开号：WO2012058645A1

  公开（公告）日：2012-05-03

  The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.