1,5-bis(4-hydroxyphenyl)-4-ferrocenyl-1H-1,2,3-triazole | 1391092-38-8

• 英文名称: 1,5-bis(4-hydroxyphenyl)-4-ferrocenyl-1H-1,2,3-triazole
• 英文别名: Fe(η5-C5H5)(η5-C5H4C2HN3C6H3(C6H4OH)2)
• CAS: 1391092-38-8
• 化学式: C₂₄H₁₉FeN₃O₂
• 分子量: 437.281
• InChiKey: IPCGYWJDMHYNAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  4-ferrocenyl-1,5-bis(4-benzyloxyphenyl)-1H-1,2,3-triazole 在 HSi(C₂H₅)3 、 catalyst: Pd/C 作用下， 以 甲醇 为溶剂， 以64%的产率得到1,5-bis(4-hydroxyphenyl)-4-ferrocenyl-1H-1,2,3-triazole
  参考文献：
  名称：

  Synthesis, electrochemistry and anticancer activity of novel ferrocenyl phenols prepared via azide-alkyne 1,3-cycloaddition reaction

  摘要：

  A series of monophenols and diphenols containing the ferrocene-C-triazolyl and ferrocene-N-triazolyl bond were prepared in a cycloaddition reaction of ethynylferrocene with aryl and benzyl azides and in a reaction of azidoferrocene with phenylacetylenes, respectively. The anticancer activity of the prepared compounds against hormone-dependent (MCF-7) and hormone-independent (HCC38) breast cancer cell lines was studied. The investigated compounds exhibited moderate anticancer activity against hormone-independent (IC50 similar to 15-48 mu M) cancer cell line and low activity against hormone-dependent cancer cell line (IC50 similar to 84-98 mu M). (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.05.042