1-Propyl-2-(tetrahydro-furan-3-yloxy)-8-[4-(thiazol-2-yloxymethyl)-bicyclo[2.2.2]oct-1-yl]-1,7-dihydro-purin-6-one | 1303955-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1-Propyl-2-(tetrahydro-furan-3-yloxy)-8-[4-(thiazol-2-yloxymethyl)-bicyclo[2.2.2]oct-1-yl]-1,7-dihydro-purin-6-one
• 英文别名: 2-(oxolan-3-yloxy)-1-propyl-8-[4-(1,3-thiazol-2-yloxymethyl)-1-bicyclo[2.2.2]octanyl]-7H-purin-6-one
• CAS: 1303955-24-9
• 化学式: C₂₄H₃₁N₅O₄S
• 分子量: 485.607
• InChiKey: ABUUFECDRGOCRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF
  申请人：Ramdas Vidya

  公开号：US20120225812A1

  公开（公告）日：2012-09-06

  The present invention provides substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The present invention also provides process of preparation of compounds of formula (I).

  本发明提供了公式（I）的取代融合嘧啶化合物，它们的互变异构体、多型体、立体异构体、前药、溶剂合物、药用可接受盐、含有它们的药物组合物以及治疗通过腺苷受体（AR）活性介导的病症和疾病的方法。本发明还提供了制备公式（I）化合物的方法。
• [EN] SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF<br/>[FR] COMPOSÉS PYRIMIDINE FUSIONNÉS SUBSTITUÉS, LEUR PRÉPARATION ET LEURS UTILISATIONS
  申请人：ADVINUS THERAPEUTICS PRIVATE LTD

  公开号：WO2011055391A1

  公开（公告）日：2011-05-12

  The present invention provides substituted fused pyrimidine compounds of formula (I), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by adenosine receptor (AR) activity. The present invention also provides process of preparation of formula (I).

  本发明提供了式(I)的取代融合嘧啶化合物，其互变异构体、多型体、立体异构体、前药、溶剂合物、药用可接受盐、含有它们的药物组合物以及治疗由腺苷受体（AR）活性介导的疾病和症状的方法。本发明还提供了制备式(I)的方法。
• US8796290B2
  申请人：——

  公开号：US8796290B2

  公开（公告）日：2014-08-05