[Ru((Cy2PO)–C7H14N2Cl)(η6-p-cymene)Cl2]Cl | 1621393-78-9

• 英文名称: [Ru((Cy2PO)–C7H14N2Cl)(η6-p-cymene)Cl2]Cl
• 英文别名: [Ru((Cy₂PO)-C₇H₁₄N₂Cl)(η⁶-p-cymene)Cl₂]Cl
• CAS: 1621393-78-9
• 化学式: C₂₉H₄₇Cl₃N₂OPRu*Cl
• 分子量: 713.561
• InChiKey: PPNFKHFMLKPVDF-VCPBINOTSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1-{3-chloro-2-[(dicyclohexylphosphanyl)oxy]propyl}-3-methylimidazolium chloride 以 二氯甲烷 为溶剂， 反应 0.5h， 以93.3%的产率得到[Ru((Cy2PO)–C7H14N2Cl)(η6-p-cymene)Cl2]Cl
  参考文献：
  名称：

  离子液体基Ru（II）-次亚膦酸酯复合物的合成及其抗氧化剂，抗菌，DNA结合和DNA裂解活性的评估

  摘要：

  摘要通过次膦酸酯官能化的咪唑鎓盐[（Ph 2 PO）C 7 H 11 N 2 Cl] Cl （1）和[（Cy 2 PO）C 7 H 11 N 2 Cl] Cl反应，合成了两种Ru（II）配合物。（2）与1/2当量的的[Ru（η 6 -对异丙基苯甲烷）（μ-Cl）的CL] 2在无水CH 2氯2并在氩气气氛下 然后将络合物分离为分析纯物质，并使用多核NMR和红外光谱及元素分析进行​​表征。Ru（II）化合物用于研究其生物学测定。为此，对自由基清除，还原能力，抗菌活性，DNA结合和DNA裂解活性进行了全面研究。从化合物4以200μg/ ml的浓度获得最大的1，1-二苯基-2-吡啶并二肼基（DPPH）清除能力和还原能力。还对该化合物针对三种革兰氏阳性细菌和三种革兰氏阴性细菌进行了测试，发现它们对革兰氏阳性细菌更有效。另外，两种化合物均显示出优异的DNA结合和DNA切割活性。 图形概要

  DOI：

  10.1007/s11696-018-00670-0
• 作为试剂：
  描述：

  对甲氧基苯乙酮 在 [Ru((Cy2PO)–C7H14N2Cl)(η6-p-cymene)Cl2]Cl 、 potassium hydroxide 作用下， 以 异丙醇 为溶剂， 生成 4-甲氧基-α-甲基苯甲醇
  参考文献：
  名称：

  Ionic liquid based Ru(II)–phosphinite compounds and their catalytic use in transfer hydrogenation: X-ray structure of an ionic compound 1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-ol

  摘要：

  The compound 1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-ol chloride (1) was prepared from the reaction of 1-methylimidazole with epichlorohydrine. The corresponding phosphinite ligands were synthesized by the reaction 1-chloro-3-(3-methylimidazolidin-1-yl)propan-2-ol chloride, [C7H15N2OCl]Cl with one equivalent of chlorodiphenylphosphine or chlorodicyclohexylphosphine, in anhydrous CH2Cl2 and under an inert argon atmosphere. [Ru(eta(6)-arene)(mu-Cl)Cl](2) dimers readily react with the phosphinite ligands [(Ph2PO)-C7H14N2Cl]Cl (2) or [(Cy2PO)-C7H14N2Cl]Cl (3) at room temperature to afford the cationic derivatives [Ru((Ph2PO)-C7H14N2Cl)(eta(6)-arene)Cl-2]Cl and [Ru((Cy2PO)-C7H14N2Cl)(eta(6)-arene)Cl-2]Cl {arene: benzene (4), (5); p-cymene (6), (7)}. The structures of these ligands and their corresponding complexes have been elucidated by a combination of multinuclear NMR and IR spectroscopy, TGA/DTA and elemental analysis. The molecular structure of the ionic compound 1 was also determined by an X-ray single crystal diffraction study. Furthermore, the catalytic activity of complexes 4-7 for the transfer hydrogenation of various ketones was investigated and these complexes were found to be efficient catalysts in the transfer hydrogenation of various ketones, with excellent conversions up to 99%. Specifically, [Ru((Cy2PO)-C7H14N2Cl)(eta(6)-benzene)Cl-2]Cl (5) and [Ru((Cy2PO)-C7H14N2Cl)(eta(6)-p-cymene)Cl-2]Cl (7) act as excellent catalysts, giving the corresponding alcohols in 98-99% conversions in 5 min (TOF <= 1188 h(-1)). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.05.079