1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methoxy]ethyl]guanidine | 71704-77-3

• 英文名称: 1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methoxy]ethyl]guanidine
• CAS: 71704-77-3
• 化学式: C₁₀H₁₆N₆O
• 分子量: 236.277
• InChiKey: LHPCNOSISJLDPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  98.1
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT
  申请人：Forma TM, LLC

  公开号：US20200283403A1

  公开（公告）日：2020-09-10

  The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.