(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-2-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)acetamide | 1346017-56-8

• 英文名称: (S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-2-(4-(4-(trifluoromethoxy)benzyl)piperazin-1-yl)acetamide
• 英文别名: N-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-2-[4-[[4-(trifluoromethoxy)phenyl]methyl]piperazin-1-yl]acetamide
• CAS: 1346017-56-8
• 化学式: C₂₀H₂₃F₃N₆O₅
• 分子量: 484.435
• InChiKey: MBQRXYSBYQKUHE-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
  申请人：Wang Tiancai

  公开号：US20130143864A1

  公开（公告）日：2013-06-06

  (6,7-Dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)amide compounds of formula (I), and their pharmaceutically acceptable salts, preparation methods and pharmaceutical compositions thereof are disclosed, wherein m and R are defined as in the description. The uses of the compounds in preparing medicaments for treating infectious diseases caused by Mycobacterium tuberculosis , especially infectious diseases caused by multi-drug resistance Mycobacterium tuberculosi are also disclosed.

  化合物(I)的(6,7-二氢-2-硝基-5H-咪唑并[2,1-b][1,3]噁嗪-6-基)酰胺及其药学上可接受的盐、制备方法和药物组合物已被披露，其中m和R的定义如描述中所述。还披露了这些化合物在制备用于治疗由结核分枝杆菌引起的传染病，特别是由多药耐药结核分枝杆菌引起的传染病的药物中的用途。
• (6,7-DIHYDRO-2-NITRO-5H-IMIDAZOL[2,1-B][1,3]OXAZIN-6-YL) AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
  申请人：Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd

  公开号：EP2573090B1

  公开（公告）日：2014-12-10
• US8563547B2
  申请人：——

  公开号：US8563547B2

  公开（公告）日：2013-10-22