dichlorido(N-(2-acetyl-2-thiazoline)-N'-(2-thiazolidin-2-one)azine)cadmium(II) | 1267597-65-8

• 英文名称: dichlorido(N-(2-acetyl-2-thiazoline)-N'-(2-thiazolidin-2-one)azine)cadmium(II)
• CAS: 1267597-65-8
• 化学式: C₈H₁₂CdCl₂N₄S₂
• 分子量: 411.658
• InChiKey: FDCKZLQQOCEYFJ-RZWKJUAESA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  N-(2-acetyl-2-thiazoline)-N'-(2-thiazolidin-2-one)azine 、 cadmium(II) chloride 以 乙醇 为溶剂， 以72%的产率得到dichlorido(N-(2-acetyl-2-thiazoline)-N'-(2-thiazolidin-2-one)azine)cadmium(II)
  参考文献：
  名称：

  Effects of a derivative thiazoline/thiazolidine azine ligand and its cadmium complexes on phagocytic activity by human neutrophils

  摘要：

  The complexes [CdCl(2)(ATHTd)] (1) and [Cd(NO(3))(2)(ATHTd)(H(2)O)] (2) [ATHTd = N-(2-acetyl-2-thiazoline)N'-(2-thiazolidin-2-one) azine] have been synthesized and characterized by a variety of physico-chemical techniques. X-ray data indicate that in 1 the coordination geometry around the metal ion can be considered a distorted square pyramid with cadmium(II) cation coordinated to one tridentate ATHTd ligand and two chloride ligands. In the case of 2, the coordination environment around Cd(II) atom approximates to a distorted pentagonal bipyramid with the cadmium atom bonded to one tridentate ATHTd ligand, one water molecule, one monodentate nitrate ligand and one bidentate nitrate ligand. The structure of ATHTd in the complexes presents an amino-2-thiazoline form instead of the iminothiazolidine one observed in free ATHTd. Likewise, the degree of rotation of the thiazoline rings around the C(1)-C(4) and C(6)-N(3) bonds has changed in complexes, which permit the coordination through thiazolinic nitrogen atoms. Besides, we study the phagocytic function in human neutrophils treated with ligand ATHTd, CdCl(2), Cd(NO(3))(2) and complexes 1 and 2. From the obtained results it can be concluded that the complexes 1 and 2 increase the phagocytic capacity of neutrophils with respect to Cd(II) salts and ATHTd. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.11.037