3-phenethyl-5-(3-phenyl-ureido)-[1,2,3]oxadiazolium betaine | 17589-96-7

• 英文名称: 3-phenethyl-5-(3-phenyl-ureido)-[1,2,3]oxadiazolium betaine
• 英文别名: N-Phenylcarbamoyl-3-(β-phenylethyl)-sydnonimin
• CAS: 17589-96-7
• 化学式: C₁₇H₁₆N₄O₂
• 分子量: 308.34
• InChiKey: SJKMSMQYNDQXET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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反应信息

• 作为产物：
  描述：

  苯胺 在 乙酸乙酯 作用下， 反应 1.5h， 生成 3-phenethyl-5-(3-phenyl-ureido)-[1,2,3]oxadiazolium betaine
  参考文献：
  名称：

  Synthesis of Molsidomine and Mesocarb Analog via Mechanochemistry

  摘要：

  Iminosydnones (ImSyds) have renowned biological activities and attractive chemical properties for chemical biology. However, access to N6‐functionalized iminosydnones involves tricky and hazardous procedures. Thanks to an innovative mechanochemical strategy using 1,1’‐carbonyldiimidazole (CDI) as an activating agent, a straightforward synthesis of molsidomine and of a mesocarb analog, two bioactive iminosydnones, was achieved. The whole process, involving 4 linear steps, was carried out in the solid state by ball‐milling and with safe reagents, offering efficient and sustainable access to N‐carbonylated iminosydnones, in agreement with the principles of green chemistry.

  DOI：

  10.1002/ejoc.202400387

文献信息

• Kholodov,L.E. et al., Journal of Organic Chemistry USSR (English Translation), 1967, vol. 3, # 8, p. 1470 - 1474
  作者：Kholodov,L.E. et al.

  DOI：——

  日期：——