3-溴-1-(对硝基苯氧基)吡啶四氟硼酸盐 | 69593-44-8

• 中文名称: 3-溴-1-(对硝基苯氧基)吡啶四氟硼酸盐
• 英文名称: 3-Bromo-1-(p-nitrophenoxy)pyridinium Tetrafluoroborate
• 英文别名: 3-bromo-1-(4-nitrophenoxy)pyridinium tetrafluoroborate
• CAS: 69593-44-8
• 化学式: BF₄*C₁₁H₈BrN₂O₃
• 分子量: 382.905
• InChiKey: ZRYCAPPFIGCIMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  3-溴-1-(对硝基苯氧基)吡啶四氟硼酸盐 在 三乙胺 作用下， 反应 1.5h， 以65%的产率得到3-bromo-2-(2-hydroxy-5-nitrophenyl)pyridine
  参考文献：
  名称：

  Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents

  摘要：

  Isosteres of cryptolepine (1) were synthesized and evaluated for their antiinfective activities. Overall, the sulfur isostere, 5-methyl benzothieno[3,2-b]quinolinium salt (5b), was equipotent to 1 and has shown no cytotoxicity at 23.8 mu g/mL. Compound 5b was also found to have a broad spectrum of activity. Both the carbon and oxygen isosteres were less potent than cryptolepine. A limited library of 2-substituted analogs of 5b has been synthesized and evaluated in antifungal screens but did not show increase in potency compared to the unsubstituted 5b. Similarly, evaluation of tricyclic benzothieno[3,2-b]pyridines while showing promise in individual screens did not produce an overall increase in potency. Overall, the evaluation of the activities of 5b compared with standard antifungal/anti-protozoal agents suggests that the benzothienoquinoline scaffold could serve as a lead for optimization. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.10.062
• 作为产物：
  描述：

  3-溴吡啶-N-氧化物 、 4-nitrobenzenediazonium tetrafluoroborate 以 乙腈 为溶剂， 反应 12.0h， 以60%的产率得到3-溴-1-(对硝基苯氧基)吡啶四氟硼酸盐
  参考文献：
  名称：

  Base-catalyzed rearrangement of N-(aryloxy)pyridinium salts. Effect of a 3-substituent in the pyridine ring upon orientation. Synthesis of novel tricyclic rings

  摘要：

  DOI：

  10.1021/jo00153a014

文献信息

• Abramovitch, Rudolph A.; Inbasekaran, Muthiah N.; Miller, Adrian L., Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 509 - 512
  作者：Abramovitch, Rudolph A.、Inbasekaran, Muthiah N.、Miller, Adrian L.、Hanna, James M.

  DOI：——

  日期：——