[nickel(II)(1-[(4-chloro-hydrazono)]propan-2-one)2(dichloride)] | 1201922-55-5

• 英文名称: [nickel(II)(1-[(4-chloro-hydrazono)]propan-2-one)2(dichloride)]
• CAS: 1201922-55-5
• 化学式: C₁₈H₁₈Cl₄N₄NiO₂
• 分子量: 522.869
• InChiKey: LAVNJLRRJMORBI-GNVODABISA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  nickel(II) chloride hexahydrate 、 1-(2-(4-chlorophenyl)hydrazono)propan-2-one 以 乙醇 为溶剂， 以61%的产率得到[nickel(II)(1-[(4-chloro-hydrazono)]propan-2-one)2(dichloride)]
  参考文献：
  名称：

  Synthesis, spectroscopic characterization and biological activity on newly synthesized copper(II) and nickel(II) complexes incorporating bidentate oxygen–nitrogen hydrazone ligands

  摘要：

  We report the synthesis of the hydrazone ligands, 1-(phenyl-hydrazono)-propan-2-one (PHP), 1-(p-tolylhydrazono)-propan-2-one (THP), 1-[(4- chloro-hydrazono)]-propan-2-one (CHP), and their Ni(II) and Cu(II) metal complexes. The structure of the ligands and their complexes were investigated using elemental analysis, magnetic susceptibility, molar conductance and spectral (IR, UV, and EPR) measurements. IR spectra indicate that the free ligands exist in the hydrazo-ketone rather than azo-enol form in the solid state. Also, the hydrazo-NH exists as hydrogen bonded to the keto-oxygen either as intra or as intermolecular hydrogen bonding. In all the studied complexes, all ligands behave as a neutral bidentate ligands with coordination involving the hydrazone-nitrogen and the keto-oxygen atoms. The magnetic and spectral data indicate a square planar geometry for Cu2+ complexes and an octahedral geometry for Ni2+ complexes. The ligands and their metal chelates have been screened for their antimicrobial activities using the disc diffusion method against the selected bacteria and fungi. They were found to be more active against Gram-positive than Gram-negative bacteria. It may be concluded that the antimicrobial activity of the compounds is related to cell wall structure of bacteria.Protonation constant of (PHP) ligand and stability constants of its Cu2+ and Ni2+ complexes were determined by potentiometric titration method in aqueous solution at ionic strength of 0.1 M sodium nitrate. It has been observed that the hydrazone ligand (PHP) titrated here has one protonation constant. The divalent metal ions Cu2+ and Ni2+ form with (PHP) 1:1 and 1:2 complexes. The insolubility of (THP) and (CHP) ligands in aqueous medium does not permit the determination of their protonation constants and formation constants of the corresponding complexes in aqueous solution. (c) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2009.08.004