(2S)-N-(2-methoxy-5-(1-methyl-1H-pyrazol-3-yl)-3-phenyl)-2-(1-(thiazol-4-yl)cyclopropylamino)propanamide | 1240522-30-8

• 英文名称: (2S)-N-(2-methoxy-5-(1-methyl-1H-pyrazol-3-yl)-3-phenyl)-2-(1-(thiazol-4-yl)cyclopropylamino)propanamide
• 英文别名: (2S)-N-[2-methoxy-5-(1-methylpyrazol-3-yl)pyridin-3-yl]-3-phenyl-2-[[1-(1,3-thiazol-4-yl)cyclopropyl]amino]propanamide
• CAS: 1240522-30-8
• 化学式: C₂₅H₂₆N₆O₂S
• 分子量: 474.586
• InChiKey: YRJMZCOYBJIZEP-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PHENYLANALINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS
  申请人：Du Xiaohui

  公开号：US20120115811A1

  公开（公告）日：2012-05-10

  Provided herein are compounds of formula I: wherein A, B, X, R 1 , R 2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.

  本文所提供的是I式化合物：其中A、B、X、R1、R2和下标n如下所述。本文还提供了包含该化合物的组合物，以及使用它们的方法，例如用于治疗2型糖尿病和2型糖尿病相关疾病的方法。
• US8785468B2
  申请人：——

  公开号：US8785468B2

  公开（公告）日：2014-07-22
• [EN] PHENYLALANINE AMIDE DERIVATIVES USEFUL FOR TREATING INSULIN-RELATED DISEASES AND CONDITIONS<br/>[FR] DÉRIVÉS DE LA PHÉNYLALANINE-AMIDE UTILES POUR LE TRAITEMENT DE MALADIES ET ÉTATS LIÉS À L'INSULINE
  申请人：AMGEN INC

  公开号：WO2010093849A2

  公开（公告）日：2010-08-19

  Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.