dichlorobis(N(4)-methyl-4-nitrobenzophenone thiosemicarbazone)manganese(II) | 1240390-41-3

• 英文名称: dichlorobis(N(4)-methyl-4-nitrobenzophenone thiosemicarbazone)manganese(II)
• CAS: 1240390-41-3
• 化学式: C₃₀H₂₈Cl₂MnN₈O₄S₂
• 分子量: 754.58
• InChiKey: FVGQESQKOIWLPN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  manganese(II) chloride tetrahydrate 、 N(4)-methyl-4-nitrobenzophenone thiosemicarbazone 以 乙醇 为溶剂， 以88%的产率得到dichlorobis(N(4)-methyl-4-nitrobenzophenone thiosemicarbazone)manganese(II)
  参考文献：
  名称：

  Manganese(II) complexes with N4-methyl-4-nitrobenzaldehyde, N4-methyl-4-nitroacetofenone, and N4-methyl-4-nitrobenzophenone thiosemicarbazone: Investigation of in vitro activity against Trypanosoma cruzi

  摘要：

  Thiosemicarbazones are known to be active against different pathogenic microorganisms including Trypanosoma cruzi, the etiological agent of Chagas disease. In the search for new therapeutic drugs against this illness, the complexes [Mn(H4NO(2)Fo4M)(2)Cl-2] (1), [Mn(H(4)NO(2)Ac4M)(2)Cl-2] (2) and [Mn(H4NO(2) Bz4M)(2)Cl-2] (3) of N-4-methyl-4-nitrobenzaldehyde thiosemicarbazone (H4NO(2)Fo4M), N-4-methyl-4-nitroacetophenone thiosemicarbazone (H4NO(2)Ac4M) and N-4-methyl-4-nitrobenzophenone thiosemicarbazone (H4NO(2)Bz4M) were obtained and screened in vitro against bloodstream and intracellular forms of T. cruzi. H4NO(2)Fo4M, H4NO(2)Ac4M and their Mn(II) complexes displayed poor effect on bloodstream trypomastigotes, with IC50 values ranging from 68 to >200 mu M. However, although H4NO(2)Bz4M was also not active, its corresponding Mn(II) complex presented high effect on this T. cruzi form, with an IC50 value of 19 mu M. The effect of complex (3), against trypomastigotes of T. cruzi supports further in vitro as well as in vivo studies. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2010.04.023