2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]acetamide | 1187325-54-7

• 英文名称: 2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]acetamide
• CAS: 1187325-54-7
• 化学式: C₈H₁₇N₃O
• 分子量: 171.242
• InChiKey: OFOLORXFOICTMS-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED PYRROLIDINE AND PIPERIDINE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR TREATING PAIN
  申请人：Attardo Giorgio

  公开号：US20110105488A1

  公开（公告）日：2011-05-05

  The present application relates to pyrrolidine, piperidine, and other nitrogen-containing heterocyclic derivatives and the use of these compounds for treating and preventing pam or inflammation. The analgesic compounds demonstrate efficacy in the treatment of neuropathic pain resulting from a variety of conditions such as diabetic neuropathy, HIV infections, and post-herpetic neuralgia.

  本申请涉及吡咯烷，哌啶和其他含氮杂环衍生物及其用于治疗和预防疼痛或炎症的用途。这些镇痛化合物在治疗由各种情况引起的神经病理性疼痛方面表现出有效性，如糖尿病神经病变，HIV感染和带状疱疹后神经痛。
• [EN] SUBSTITUTED PYRROLIDINE AND PIPERIDINE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR TREATING PAIN<br/>[FR] COMPOSÉS DE PYRROLIDINE ET DE PIPÉRIDINE SUBSTITUÉS, LEURS DÉRIVÉS ET PROCÉDÉS DE TRAITEMENT DE LA DOULEUR
  申请人：CHLORION PHARMA INC

  公开号：WO2009114950A1

  公开（公告）日：2009-09-24

  The present application relates to pyrrolidine, piperidine, and other nitrogen-containing heterocyclic derivatives and the use of these compounds for treating and preventing pam or inflammation. The analgesic compounds demonstrate efficacy in the treatment of neuropathic pain resulting from a variety of conditions such as diabetic neuropathy, HIV infections, and post-herpetic neuralgia.