N-2-(6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-N-(1-{1,1-dimethyl-2-[(2-methylbenzyl)amino]-2-oxoethyl}-1H-imidazol-4-yl)-O-methyl-L-serinamide | 930098-67-2

• 英文名称: N-2-(6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-N-(1-{1,1-dimethyl-2-[(2-methylbenzyl)amino]-2-oxoethyl}-1H-imidazol-4-yl)-O-methyl-L-serinamide
• 英文别名: 2-[4-[[(2S)-2-[(6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino]-3-methoxypropanoyl]amino]imidazol-1-yl]-2-methyl-N-[(2-methylphenyl)methyl]propanamide
• CAS: 930098-67-2
• 化学式: C₂₉H₃₅F₂N₅O₃
• 分子量: 539.625
• InChiKey: LHOHLJKCGPGDBD-TUXUZCGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  97.3
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Imidazole compounds for the treatment of neurological disorders
  申请人：Brodney A. Michael

  公开号：US20070066613A1

  公开（公告）日：2007-03-22

  The present invention relates to compounds of Formula I wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 and A are as defined. Compounds of Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.

  本发明涉及公式I中的化合物，其中R1、R2、R3、R4、R6、R7和A如定义。公式I的化合物具有抑制Aβ肽产生活性。该发明还涉及包含公式I化合物的药物组合物和治疗疾病和紊乱的方法，例如在哺乳动物中治疗神经退行性和/或神经系统疾病，例如阿尔茨海默病。
• IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Brodney Michael A.

  公开号：US20100184737A1

  公开（公告）日：2010-07-22

  The present invention relates to compounds of Formula I wherein R 1 , R 2 , R 3 , R 4 , R 6 , R 7 and A are as defined. Compounds of Formula I have activity inhibiting production of Aβ-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.

  本发明涉及公式I的化合物，其中R1、R2、R3、R4、R6、R7和A的定义如下。公式I的化合物具有抑制Aβ肽的产生活性。本发明还涉及制备公式I化合物的药物组合物和治疗疾病和障碍的方法，例如神经退行性和/或神经系统疾病，例如阿尔茨海默病，在哺乳动物中包括公式I化合物。
• US7781435B2
  申请人：——

  公开号：US7781435B2

  公开（公告）日：2010-08-24