[Au(4,4′-dimethyl-2,2′-bipyridine)Cl₂][AuCl₄] | 1620496-00-5

• 英文名称: [Au(4,4′-dimethyl-2,2′-bipyridine)Cl₂][AuCl₄]
• 英文别名: [Au(4,4′-dmbipy)Cl₂][AuCl₄]
• CAS: 1620496-00-5
• 化学式: AuCl₄*C₁₂H₁₂AuCl₂N₂
• 分子量: 790.892
• InChiKey: DPABIEQUHDNIMT-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  4,4'-二甲基-2,2'-联吡啶 、 四氯金酸水合物 以 乙醇 、 乙腈 为溶剂， 反应 0.25h， 以72.8%的产率得到[Au(4,4′-dimethyl-2,2′-bipyridine)Cl₂][AuCl₄]
  参考文献：
  名称：

  Synthesis and characterization of a series of gold(III) complexes with the 4,4′-dimethyl-2,2′-bipyridine ligand: Counterion influence on the cytotoxicity of gold(III) complexes

  摘要：

  A series of Au(III) complexes, [Au(4,4'-dmbipy)X-2]Y-+(-) where X = Cl, Br and Y = [AuCl4], [AuCl2], [ClO4], [AuBr4], were prepared from the reactions of HAuCl4 center dot 3H(2)O/AuBr3 with 4,4'-dimethy1-2,2'-bipyridine (4,4'-dmbipy) in a mixture of alcohol/CH3CN. These complexes were characterized by elemental analysis, IR, UV-Vis, H-1 and C-13 NMR spectroscopy and their structures were studied by the single-crystal diffraction method. The electrochemical behavior of the title complexes were also studied in CH3CN and DMSO using cyclic voltammetry. The cationic parts of the complexes are similar, with a bidentate nitrogenous 4,4'-dmbipy ligand and two halide anions attached to a gold(III) center in a square-planar geometry. However, the effect of the anionic parts of the complexes on the cytotoxic properties was evaluated in four cultures, Vero, A431, HeLa and HT-29 by means of an MTT assay. The results illustrate that the anion part plays an important role in the cytotoxicity of relevant compounds in different cell lines. Complexes 1 and 4, with the similar anion part of [AuX4](-) (X = Cl and Br), displayed good agreement in their anticancer activities toward human cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.04.064