cis-[Ru(dipyrido[3,2-a:2',3'-c]phenazine)2Cl2] | 132045-68-2

• 英文名称: cis-[Ru(dipyrido[3,2-a:2',3'-c]phenazine)2Cl2]
• CAS: 132045-68-2；766541-21-3
• 化学式: C₃₆H₂₀Cl₂N₈Ru
• 分子量: 736.584
• InChiKey: ZWTWZMKXZNFPAG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  ammonium hexafluorophosphate 、 cis-[Ru(dipyrido[3,2-a:2',3'-c]phenazine)2Cl2] 、 1,7,10,17,23,26-Hexazaoctacyclo[15.15.1.02,15.03,8.09,14.018,31.019,24.025,30]tritriaconta-2,4,6,8,10,12,14,18,20,22,24,26,28,30-tetradecaene 以 水 、 乙二醇 为溶剂， 以24%的产率得到[Ru2(dipyrido[3,2-a:2',3'-c]phenazine)4(bis-phenanthroline-Troegers base)][PF6]4
  参考文献：
  名称：

  Binuclear ruthenium(II) polypyridyl complexes: DNA cleavage and mitochondria mediated apoptosis induction

  摘要：

  Binuclear complexes of the type [Ru-2(N-N)(4)(TBPhen(2))](4+), where N-N = 2,2'-bipyridine (bpy) (1), 1,10-phenanthroline (phen) (2), dipyrido[3,2-a:2',3'-c]phenazine (dppz) (3) and (TBPhen(2)) = bis-phenanthroline Troger's Base analogue, have been synthesized and characterized by H-1 NMR, IR, UV-Vis, elemental analysis, ESI-Mass spectroscopy and cyclic voltammetry. The DNA binding characteristics of the complexes have been investigated by absorbance, steady-state emission, thermal melting and viscosity measurements. Photophysical studies reveal that [Ru-2(TBPhen(2))(dppz)(4)](4+) interacts with calf thymus DNA with an intrinsic binding constant of (8.75 +/- 1.11 x 10(6) M-1). DNA cleavage studies of complexes 1-3 have been investigated using gel electrophoresis. The cytotoxicity of all the complexes against the HeLa cell line was evaluated by MTT assay and the status of mitochondria by real time living cell microscopy indicates apoptosis induction by complexes 1 and 2, further corroborated by a fluorescence microscopy-TUNEL assay. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.01.024