3-[1'-(4-cyano-2-methoxybenzoyl)-1',2',3',6'-tetrahydro-3,4'-bipyridin-6-yl]-N-(2,6-dichlorobenzoyl)-L-alanine | 938083-53-5

• 英文名称: 3-[1'-(4-cyano-2-methoxybenzoyl)-1',2',3',6'-tetrahydro-3,4'-bipyridin-6-yl]-N-(2,6-dichlorobenzoyl)-L-alanine
• 英文别名: (2S)-3-[5-[1-(4-cyano-2-methoxybenzoyl)-3,6-dihydro-2H-pyridin-4-yl]pyridin-2-yl]-2-[(2,6-dichlorobenzoyl)amino]propanoic acid
• CAS: 938083-53-5
• 化学式: C₂₉H₂₄Cl₂N₄O₅
• 分子量: 579.439
• InChiKey: CGVZQQVITNMUOR-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• L-ALANINE DERIVATIVES
  申请人：Kettle Grant Jason

  公开号：US20090111828A1

  公开（公告）日：2009-04-30

  The present invention relates to compounds that inhibit of a5 b 1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5 b 1 and also that exhibit appropriate selectivity profile(s) against other integrins.

  本发明涉及抑制a5b1功能的化合物，其制备过程，含有其作为活性成分的制药组合物，以及它们作为药物的使用和用于制造药物以治疗温血动物（如人类）中具有显著血管生成或血管成分的疾病，如固体肿瘤的治疗。本发明还涉及抑制a5b1并且对其他整合素具有适当选择性特征的化合物。