| 1573116-95-6

• CAS: 1573116-95-6
• 化学式: C₆₃H₅₃BN₂OP₂Pd
• 分子量: 1033.31
• InChiKey: RYGCSFWGKPVTNY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  四(三苯基膦)钯 、 三苯基硼烷 、 N-cyano-N-phenylacetamide 以 苯 为溶剂， 反应 2.0h， 以58%的产率得到
  参考文献：
  名称：

  Intramolecular Aminocyanation of Alkenes by Cooperative Palladium/Boron Catalysis

  摘要：

  A cooperative palladium/triorganoboron catalyst to accomplish the intramolecular aminocyanation of alkenes through the cleavage of N-CN bonds is reported. 4,5-Bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) is found to be crucial as a ligand for palladium to effectively catalyze the transformation with high chemo- and regioselectivity. A range of substituted indolines and pyrrolidines with both tetra- or trisubstituted carbon and cyano functionalities are readily furnished by the newly developed cyanofunctionalization reaction. A preliminary example of enantioselective aminocyanation is also described.

  DOI：

  10.1021/ja4122632