[Ir(2-phenylpyridine(-H))2(4,7-dimethyl-1,10-phenanthroline)](hexafluorophosphate) | 958243-01-1

• 英文名称: [Ir(2-phenylpyridine(-H))2(4,7-dimethyl-1,10-phenanthroline)](hexafluorophosphate)
• 英文别名: [Ir(ppy)2(4-Me,7-Me-1,10-phen)]PF6
• CAS: 958243-01-1
• 化学式: C₃₆H₂₈IrN₄*F₆P
• 分子量: 853.829
• InChiKey: IPDYBDRFFHMZDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  ammonium hexafluorophosphate 、 以 甲醇 、 二氯甲烷 、 水 为溶剂， 生成 [Ir(2-phenylpyridine(-H))2(4,7-dimethyl-1,10-phenanthroline)](hexafluorophosphate)
  参考文献：
  名称：

  A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

  摘要：

  摘要：受损伤口愈合和溃疡并发症是糖尿病患者死亡的主要原因。在这项研究中，我们报道了一种环金属化的铱（III）金属配合物1a的设计和合成，作为缺氧诱导因子-1α（HIF-1α）的稳定剂。体外生物物理和细胞分析表明，该化合物结合Von Hippel-Lindau（VHL）并抑制VHL-HIF-1α相互作用。此外，该化合物在细胞内累积HIF-1α水平，并激活HIF-1α介导的基因表达，包括VEGF、GLUT1和EPO。在活体小鼠模型中，该化合物显著加快了正常和糖尿病小鼠的伤口闭合速度，糖尿病组效果更显著。我们还证明了与伤口愈合相关的HIF-1α驱动基因（如HSP-90、VEGFR-1、SDF-1、SCF和Tie-2）在1a处理的糖尿病小鼠（包括db/db、HFD/STZ和STZ模型）的伤口组织中增加。我们的研究证明了一种小分子稳定剂HIF-1α作为治疗伤口愈合的有前途的药物，并更重要的是，通过阻断VHL和HIF-1α相互作用验证了治疗糖尿病伤口的可行性。

  DOI：

  10.1038/s41467-021-23448-7

文献信息

• The Role of Substituents on Functionalized 1,10-Phenanthroline in Controlling the Emission Properties of Cationic Iridium(III) Complexes of Interest for Electroluminescent Devices
  作者：Claudia Dragonetti、Luigi Falciola、Patrizia Mussini、Stefania Righetto、Dominique Roberto、Renato Ugo、Adriana Valore、Filippo De Angelis、Simona Fantacci、Antonio Sgamellotti、Miguel Ramon、Michele Muccini

  DOI：10.1021/ic700414z

  日期：2007.10.1

  The photophysical and electrochemical properties of the novel complexes [Ir(ppy)(2)(5-X-1,10-phen)][PF6] (ppy = 2-phenylpyridine, phen = phenanthroline, X = NMe2, NO2), [Ir(pq)(2)(5-X-1,10-phen)][PF6] (pq = 2-phenylquinoline, X, = H, Me, NMe2, NO2), [Ir(ppy)(2)(4-Me,7-Me-1,10-phen)][PF6], [Ir(ppy)(2)(5-Me,6-Me-1,10-phen)][PF6], [Ir(ppy)(2)(2-Me,9-Me-1,10-phen)][PF6], and [Ir(pq)(2)(4-Ph,7-Ph-1,10-phen)][PF6] have been investigated and compared with those of the known reference complexes [Ir(ppy)(2)(4-Me or 5-H or 5-Me-1,10-phen)][PF6] and [Ir(ppy)(2)(4-Ph,7-Ph-1,10-phen)][PF6], showing how the nature and number of the phenanthroline substituents tune the color of the emission, its quantum yield, and the emission lifetime. It turns out that the quantum yield is strongly dependent on the nonradiative decay. The geometry, ground state, electronic structure, and excited electronic states of the investigated complexes have been calculated on the basis of density functional theory (DFT) and time-dependent DFT approaches, thus substantiating the electrochemical measurements and providing insight into the electronic origin of the absorption spectra and of the lowest excited states involved in the light emission process. These results provide useful guidelines for further tailoring of the photophysical properties of ionic Ir(III) complexes.