| 136166-30-8

• CAS: 136166-30-8；136234-85-0
• 化学式: C₁₄H₁₆Cl₂O₂PtS₂
• 分子量: 546.398
• InChiKey: NUYSNJWNYCEJJV-UCJAQVTMSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 甲基苯基亚砜 以 水 为溶剂， 反应 12.0h， 以67%的产率得到
  参考文献：
  名称：

  CATALYST FOR PRODUCING METHANOL PRECURSOR, METHANOL PRECURSOR PRODUCED USING THE CATALYST AND METHANOL PRODUCED USING THE METHANOL PRECURSOR

  摘要：

  公开了一种用于生产甲醇前体的新型催化剂。该催化剂的使用使得在低温低压条件下高效生产甲醇前体和甲醇成为可能。还公开了使用该催化剂生产的甲醇前体以及使用甲醇前体生产的甲醇。

  公开号：

  US20180179130A1

文献信息

• Stereoselective [2 + 3] cycloaddition of nitrones to platinum-bound organonitriles. First enantioselective synthesis of Δ4-1,2,4-oxadiazolines†
  作者：Gabriele Wagner、Matti Haukka

  DOI：10.1039/b102291c

  日期：——

  Coordinated benzonitrile in cis-[PtCl2(R3MeSO)(PhCN)] (R3 = Me, Ph) is sufficiently activated to undergo [2 + 3] cycloaddition with nitrones −O+N(R2)CH(R1) (R1 = Ph, p-C6H4Me, p-C6H4OMe, R2 = Me; R1 = Ph, R2 = CH2Ph) under mild conditions to give the corresponding Δ4-1,2,4-oxadiazoline complexes cis-[PtCl2(R3MeSO)NC(Ph)–ON(R2)–CH(R1)}] in 68–83% yield. In this reaction, the chiral sulfoxide in cis-[PtCl2(PhMeSO)(PhCN)] induces stereoselective formation of the coordinated Δ4-1,2,4-oxadiazoline leading to mixtures of diastereomeric platinum complexes with a d.e. of 30–60%, which can be enhanced to >90% by fractional crystallization. The major diastereoisomer of [PtCl2(PhMeSO)NC(Ph)–ON(Me)–C(H)Ph}] thus obtained was analyzed by X-ray diffraction and shown to have cis-(R,S) configuration.Reaction of cis-[PtCl2(R3MeSO)NC(Ph)–ON(R2)–CH(R1)}] with ethane-1,2-diamine results in displacement of the Δ4-1,2,4-oxadiazolines from the metal and concomitant formation of water-soluble [Pt(en)2]Cl2 and sulfoxide, which can both be removed by aqueous extraction, and this allows for the first time the isolation of Δ4-1,2,4-oxadiazolines in enantiomerically enriched form. Applying this technique to cis-(RS,SC)-[PtCl2(PhMeSO)NC(Ph)–ON(Me)–C(H)Ph}] of 90% d.e. and 79% e.e. in sulfoxide, the corresponding (R)-2-methyl-3,5-diphenyl-Δ4-1,2,4-oxadiazoline was obtained with 70% e.e.

  顺式-[PtCl2(R3MeSO)(PhCN)]（R3Â =Â Me，Ph）中的配位苯腈被充分活化，与硝基化合物âO+N(R2)CH(R1)（R1Â =Â Ph，p-C6H4Me，p-C6H4OMe，R2Â =Â Me）发生[2Â +Â 3]环加成反应；R1Â=ÂPh，R2Â=ÂCH2Ph），得到相应的δ4-1,2,4-噁二唑啉配合物顺式-[PtCl2(R3MeSO)NC(Ph)âON(R2)âCH(R1)}]，收率为 68â83% 。在该反应中，顺式-[PtCl2(PhMeSO)(PhCN)]中的手性亚砜诱导了配位δ4-1,2,4-恶二唑啉的立体选择性形成，导致非对映异构体铂络合物混合物的d.e.为30â60%，通过分馏结晶可提高到大于90%。通过 X 射线衍射分析表明，由此获得的[PtCl2(PhMeSO)NC(Ph)âON(Me)âC(H)Ph}]的主要非对映异构体具有顺式（R，S）构型。顺式[PtCl2(R3MeSO)NC(Ph)âON(R2)âCH(R1)}]与乙烷-1,2-二胺反应后，δ4-1,2,4-噁二唑啉从金属中移出，同时形成水溶性[Pt(en)2]Cl2和亚砜、这样就首次分离出了对映体富集形式的δ4-1,2,4-恶二唑啉。将这种技术应用于在亚砜中对映体含量分别为 90% 和 79% 的顺式-(RS,SC)-[PtCl2(PhMeSO)NC(Ph)âON(Me)âC(H)Ph}]，得到了相应的(R)-2-甲基-3,5-二苯基δ4-1,2,4-恶二唑啉，对映体含量为 70%。