(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;sulfuric acid | 52732-58-8

• 英文名称: (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;sulfuric acid
• CAS: 52732-58-8
• 化学式: C16H21N3O8S2
• 分子量: 447.5
• InChiKey: VUUFCYRFLGPJIJ-YWUHCJSESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.33
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  221
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Recombinant Alzheimer's amyloid protein
  申请人：CALIFORNIA BIOTECHNOLOGY, INC.

  公开号：EP0274826A1

  公开（公告）日：1988-07-20

  DNA sequences encoding the β-amyloid core protein, and β-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant β-amyloid core protein, β-amyloid-related proteins and recombinant or synthetic immunogenic peptides. These sequences are also used to identify genomic mutations and/or restriction site alterations which are associated with a predisposition to Alzheimer's disease, for purposes of genetic screening. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

  本研究公开了编码与阿尔茨海默病相关的β淀粉样核心蛋白和β淀粉样相关蛋白的DNA序列。这些序列可用于生产或构建重组β-淀粉样核心蛋白、β-淀粉样相关蛋白和重组或合成免疫原肽。这些序列还可用于鉴定与阿尔茨海默病易感性相关的基因组突变和/或限制位点改变，以进行基因筛选。针对重组蛋白或由其衍生的免疫原肽产生的抗体可用于阿尔茨海默病的脑液或血清蛋白诊断。
• ANTI-IgSF4 ANTIBODY AND UTILIZATION OF THE SAME
  申请人：Institute for Antibodies Co., Ltd.

  公开号：EP1860119A1

  公开（公告）日：2007-11-28

  It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressen in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treatig cancer, etc.

  其目的是明确可作为治疗或诊断癌症靶点的分子，并将该分子用于医疗或研究领域。IgSF4 已被确定为肺癌细胞中特异性表达的分子，通过用抗体对其进行处理，可发挥 ADCC 活性。基于这一发现，提供了一种抗 IgSF4 抗体，作为治疗癌症等的有效手段。
• METHOD OF CLASSIFYING ANTIGEN, METHOD OF IDENTIFYING ANTIGEN, METHOD OF OBTAINING ANTIBODY OR ANTIBODY SET, METHOD OF CONSTRUCTING ANTIBODY PANEL AND ANTIBODY OR ANTIBODY SET AND USE OF THE SAME
  申请人：Institute for Antibodies Co., Ltd.

  公开号：EP2078732A1

  公开（公告）日：2009-07-15

  It is intended to provide a method whereby a plural number of antibodies against cell surface antigens are quickly classified and to provide a method whereby antigens of the thus classified antibodies are quickly identified. Further, it is intended to provide a method of promoting the utilization of the useful data obtained by the above methods. Furthermore, it is intended to provide an antibody which is effective in treating or diagnosing cancer. Namely, a method of classifying antibodies which comprises: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data and classifying the individual antibodies depending on the similarity. A method of identifying antigens which further comprises: (5) the step of selecting one to several antibodies from each antibody group formed in the step (4) and identifying antigens thereof; and (6) on the assumption that antigens of the antibodies belonging to a single antibody group are the same or highly related to one another, making relations between the antigens having been identified in the step (5) and the antibody groups to thereby identify the antigens. An antibody against HER1, an antibody against HER2, an antibody against CD46, an antibody against ITGA3, an antibody against ICAM1, an antibody against ALCAM, an antibody against CD147, an antibody against C1qR, an antibody against CD44, an antibody against CD73, an antibody against EpCAM and an antibody against HGFR, each obtained by using the above methods.

  本发明的目的是提供一种方法，据此可快速对针对细胞表面抗原的多种抗体进行分类，并提供一种方法，据此可快速识别已分类抗体的抗原。此外，还打算提供一种促进利用通过上述方法获得的有用数据的方法。此外，还希望提供一种能有效治疗或诊断癌症的抗体。也就是说，一种对抗体进行分类的方法，它包括：(1) 制备多个分别识别细胞表面抗原的抗体；(2) 使这些抗体分别与同种细胞接触；(3) 用流式细胞仪分析在步骤(2)中处理过的每个细胞，从而获得表明每个抗体与其细胞表面抗原反应性的数据；(4) 比较由此获得的数据，并根据相似性对各个抗体进行分类。一种鉴定抗原的方法，进一步包括：(5) 从步骤(4)中形成的每个抗体组中选择一至数个抗体并鉴定其抗原的步骤；以及(6) 假定属于单个抗体组的抗体的抗原相同或彼此高度相关，在步骤(5)中鉴定的抗原与抗体组之间建立联系，从而鉴定抗原。通过上述方法分别获得抗 HER1 抗体、抗 HER2 抗体、抗 CD46 抗体、抗 ITGA3 抗体、抗 ICAM1 抗体、抗 ALCAM 抗体、抗 CD147 抗体、抗 C1qR 抗体、抗 CD44 抗体、抗 CD73 抗体、抗 EpCAM 抗体和抗 HGFR 抗体。
• COMPOSITION FOR NEUTRALIZING BOTULINUS TOXIN TYPE-A, AND HUMAN ANTI-BOTULINUS TOXIN TYPE-A ANTIBODY
  申请人：Institute for Antibodies Co., Ltd.

  公开号：EP2246426A1

  公开（公告）日：2010-11-03

  Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.

  本文提供了一种有效治疗肉毒杆菌疾病和预防肉毒杆菌疾病的方法。具体提供了具有不同表位的多种人类抗 A 型肉毒毒素抗体。还特别提供了一种用于中和A型肉毒毒素的组合物，该组合物由两种或两种以上抗体组合而成，具有很高的中和活性。
• NOVEL ANTI-CD73 ANTIBODY
  申请人：Fujita Health University

  公开号：EP2975057A1

  公开（公告）日：2016-01-20

  An antibody against CD73 obtained by a method comprising: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data.

  一种抗 CD73 的抗体，其制备方法包括：(1) 制备多种分别识别细胞表面抗原的抗体；(2) 使每种抗体与同种细胞接触；(3) 用流式细胞仪分析在步骤(2)中处理过的每种细胞，从而获得表明每种抗体与其细胞表面抗原反应性的数据；(4) 比较由此获得的数据。