(R)-2-[(S)-(2-fluorophenoxy)(4-fluorophenyl)methyl]morpholine | 868685-85-2

• 英文名称: (R)-2-[(S)-(2-fluorophenoxy)(4-fluorophenyl)methyl]morpholine
• 英文别名: (2R)-2-[(S)-(2-fluorophenoxy)-(4-fluorophenyl)methyl]morpholine
• CAS: 868685-85-2
• 化学式: C₁₇H₁₇F₂NO₂
• 分子量: 305.324
• InChiKey: CQIVBAXHOAFIAL-SJORKVTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Substituted morpholine compounds for the treatment of central nervous system disorders
  申请人：Barta S. Nancy

  公开号：US20050245519A1

  公开（公告）日：2005-11-03

  This invention relates to compounds of the formulae I wherein R 1 -R 8 , A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.

  这项发明涉及到公式I中的化合物，其中R1-R8，A，X和Z的定义如规范中所述，包含它们的药物组合物以及它们在治疗中枢神经系统疾病中的用途。
• SUBSTITUTED MORPHOLINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Warner-Lambert Company LLC

  公开号：EP1745029A1

  公开（公告）日：2007-01-24
• US7659394B2
  申请人：——

  公开号：US7659394B2

  公开（公告）日：2010-02-09
• [EN] SUBSTITUTED MORPHOLINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS<br/>[FR] COMPOSES DE MORPHOLINE SUBSTITUES PERMETTANT DE TRAITER DES TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：WARNER LAMBERT CO

  公开号：WO2005105763A1

  公开（公告）日：2005-11-10

  This invention relates to compounds of the formulae (I), (II), (III), wherein R'- Re, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.