[RuCl₂([9]aneS₃)(S-dmso)]*2H₂O | 157598-10-2

• 英文名称: [RuCl₂([9]aneS₃)(S-dmso)]*2H₂O
• 英文别名: [RuCl₂(1,4,7-trithiacyclononane)(S-dmso)]*2H₂O
• CAS: 157598-10-2
• 化学式: C₈H₁₈Cl₂ORuS₄*2H₂O
• 分子量: 466.501
• InChiKey: MRUZWSJLNTVBJA-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [RuCl₂([9]aneS₃)(S-dmso)]*2H₂O 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Structure and reactions of the thioether half-sandwich ruthenium(II) complexes [Ru(MeCN)3([9]aneS3)][CF3SO3]2 and [Ru(MeCN)2(PPh3)([9]aneS3)][CF3SO3]2([9]aneS3= 1,4,7-trithiacyclononane)

  摘要：

  The complex [Ru(MeCN)3([9]aneS3)][CF3SO3]2 ([9]aneS3 = 1,4,7-trithiacyclononane) was prepared by reaction of [RuCl2(dmso)([9]aneS3)] 1 (dmso = dimethyl sulfoxide) with Ag(CF3SO3) in acetonitrile. It has been employed as a starting material for the synthesis of the mixed-ligand sandwich complexes [Ru{HB(pz)3}([9]aneS3)][CF3SO3] 3 (pz = pyrazol-1-yl) and [Ru{HC(pz)3}([9]aneS3)][CF3SO3]2 4 and the dinuclear half-sandwich complex [{Ru(mu-S2CNMe2)([9]aneS3)}2][CF3SO3]2 5. The complex [Ru(MeCN)2(PPh3)([9]aneS3)][CF3SO3]2 6 may likewise be used for the preparation of thioether half-sandwich ruthenium(II) complexes such as [Ru(S2CNMe2)(PPh3)([9]aneS3)][CF3SO3] 7 and [Ru(C7H4NS2)(PPh3)([9]aneS3)][CFSO3] 8 (C7H4NS2 = 2-sulfanylbenzothiazolate). The structures of 1, 2 and 5-7 have been determined by X-ray crystallography.

  DOI：

  10.1039/dt9940001885
• 作为产物：
  描述：

  1,4,7-三硫环壬烷 、 tetrakis(dimethylsulfoxide)dichlororuthenium(II) 以 氯仿 为溶剂， 以91%的产率得到[RuCl₂([9]aneS₃)(S-dmso)]*2H₂O
  参考文献：
  名称：

  Structure and reactions of the thioether half-sandwich ruthenium(II) complexes [Ru(MeCN)3([9]aneS3)][CF3SO3]2 and [Ru(MeCN)2(PPh3)([9]aneS3)][CF3SO3]2([9]aneS3= 1,4,7-trithiacyclononane)

  摘要：

  The complex [Ru(MeCN)3([9]aneS3)][CF3SO3]2 ([9]aneS3 = 1,4,7-trithiacyclononane) was prepared by reaction of [RuCl2(dmso)([9]aneS3)] 1 (dmso = dimethyl sulfoxide) with Ag(CF3SO3) in acetonitrile. It has been employed as a starting material for the synthesis of the mixed-ligand sandwich complexes [Ru{HB(pz)3}([9]aneS3)][CF3SO3] 3 (pz = pyrazol-1-yl) and [Ru{HC(pz)3}([9]aneS3)][CF3SO3]2 4 and the dinuclear half-sandwich complex [{Ru(mu-S2CNMe2)([9]aneS3)}2][CF3SO3]2 5. The complex [Ru(MeCN)2(PPh3)([9]aneS3)][CF3SO3]2 6 may likewise be used for the preparation of thioether half-sandwich ruthenium(II) complexes such as [Ru(S2CNMe2)(PPh3)([9]aneS3)][CF3SO3] 7 and [Ru(C7H4NS2)(PPh3)([9]aneS3)][CFSO3] 8 (C7H4NS2 = 2-sulfanylbenzothiazolate). The structures of 1, 2 and 5-7 have been determined by X-ray crystallography.

  DOI：

  10.1039/dt9940001885

文献信息

• Synthesis, reactivities and anti-cancer properties of ruthenium(II) complexes with a thiaether macrocyclic ligand
  作者：Hannah A. O’Riley、Aviva Levina、Jade B. Aitken、Peter A. Lay

  DOI：10.1016/j.ica.2016.07.050

  日期：2017.1

  promising anti-cancer drugs. A series of Ru II complexes [RuX 2 ([9]aneS 3 )( S -dmso)] (X = Cl, Br, I, S -dmso = sulfur-bound dimethylsulfoxide) containing the neutral face-capping sulfur macrocycle ligand, 1,4,7-trithiacyclononane ([9]aneS 3 ) was synthesized, characterized and their substitution reactions and biological activities were investigated. While the iodido complex was not sufficiently soluble

  摘要Pt药物的耐药性和严重的患者副作用刺激了对其他金属基药物的研究，近来Ru复合物已被确认为有前途的抗癌药物。一系列的Ru II配合物[RuX 2（[9] aneS 3）（S -dmso）]（X = Cl，Br，I，S -dmso =硫键合的二甲亚砜），含有中性的封端硫大环配体，合成了1,4,7-三硫代环壬烷（[9] aneS 3），对其进行了表征，并对它们的取代反应和生物学活性进行了研究。尽管碘仿复合物不能充分溶解用于详细研究，研究[RuCl 2（[9] aneS 3）（S -dmso）]和[RuBr 2（[9] aneS 3）（S -dmso）]，以确定卤代配体取代率之间是否存在直接关系（由紫外/可见光谱和X射线吸收光谱确定）和抗癌活性。HEPES缓冲液（pH 7.4，310 K）中发生了两个阶段的卤素取代过程。氯代取代的速率常数比溴代类似物的速率常数大两倍（氯代复合物的（4.5±0.2）×10