N-[(3R)-1-(cyclopropylmethyl)piperidin-3-yl]-3-methoxy-4-[[4-[[4-methyl-2-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | 1226992-32-0

• 英文名称: N-[(3R)-1-(cyclopropylmethyl)piperidin-3-yl]-3-methoxy-4-[[4-[[4-methyl-2-[methyl(methylsulfonyl)amino]phenyl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide
• CAS: 1226992-32-0
• 化学式: C₃₂H₄₀F₃N₇O₄S
• 分子量: 675.775
• InChiKey: GTIIRDUXFJFPCO-XMMPIXPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  137
• 氢给体数：
  3
• 氢受体数：
  13

文献信息

• 2,4-DIAMINOPYRIMIDINE DERIVATES AS PTK2- INHIBITORS FOR THE TREATMENT OF ABNORMAL CELL GROWTH
  申请人：Sapountzis Ioannis

  公开号：US20110275633A1

  公开（公告）日：2011-11-10

  The present invention encompasses compounds of general formula (1) wherein R 1 -R 3 and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

  本发明涵盖了通式（1）中R1-R3和n的定义如权利要求1所述的化合物，适用于治疗由过度或异常细胞增殖所特征的疾病，并且它们用于制备具有上述特性的药物。