(5R)-N5-(2-Cyano-2-methylpropyl)-3-(4-fluorobenzyl)-10-hydroxy-N9,5-dimethyl-8-oxo-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de][1,5]naphthyridine-5,9-dicarboxamide | 1206527-12-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (5R)-N5-(2-Cyano-2-methylpropyl)-3-(4-fluorobenzyl)-10-hydroxy-N9,5-dimethyl-8-oxo-5,6-dihydro-8H-[1,4]oxazino[2,3,4-de][1,5]naphthyridine-5,9-dicarboxamide
• 英文别名: (3R)-3-N-(2-cyano-2-methylpropyl)-6-[(4-fluorophenyl)methyl]-10-hydroxy-11-N,3-dimethyl-12-oxo-4-oxa-1,8-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,10-tetraene-3,11-dicarboxamide
• CAS: 1206527-12-9
• 化学式: C₂₆H₂₆FN₅O₅
• 分子量: 507.521
• InChiKey: CUSBNKCGCYWLLO-AREMUKBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  145
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Aktoudianakis Evangelos

  公开号：US20100022508A1

  公开（公告）日：2010-01-28

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  这项发明涉及抗病毒化合物，含有这种化合物的组合物，以及包括给予这种化合物的治疗方法，还涉及用于制备这种化合物的过程和中间体。
• US7998950B2
  申请人：——

  公开号：US7998950B2

  公开（公告）日：2011-08-16
• [EN] ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX
  申请人：GILEAD SCIENCES INC

  公开号：WO2010011959A1

  公开（公告）日：2010-01-28

  The invention is related to anti-viral compounds of formula (I), compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.