4-(2-(2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetyl)benzonitrile hydrobromide | 1282523-66-3

• 英文名称: 4-(2-(2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetyl)benzonitrile hydrobromide
• CAS: 1282523-66-3
• 化学式: BrH*C₁₆H₁₂N₄O
• 分子量: 357.209
• InChiKey: LZYSNGHGEKLSCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.78
• 重原子数：
  22.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  85.43
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  2-氨基苯并咪唑 、 2-溴-4'-氰基苯乙酮 以 乙醇 为溶剂， 反应 1.5h， 以60%的产率得到4-(2-(2-imino-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetyl)benzonitrile hydrobromide
  参考文献：
  名称：

  Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

  摘要：

  Since activation of p53 in response to cytotoxic stress may have proapoptotic or protective effects depending on the nature of the injury, inhibitors of p53 may have therapeutic interest as modulators of chemotherapy toxicity or efficacy. In an attempt to identify novel p53 inhibitors, a quality collection of compounds structurally related to pifithrin-beta were designed and synthesized as potential inhibitors of p53. The biochemical and biological evaluations supported that compounds of the tetrahydrobenzothiazole series were inhibitors of the p53 transcriptional activity and were effective in enhancing paclitaxel-induced apoptosis. In contrast, in spite of the increased cytotoxic potency, selected compounds of the benzothiazole series were not able to modulate the transcriptional activity of p53, as indicated by lack of change of p21 expression. The therapeutic interest of the compounds of the former series in combination with taxanes was confirmed in a human tumor xenograft model. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.01.039