dichloro(O-methylselenomethionine)platinum(II) | 905854-81-1

• 英文名称: dichloro(O-methylselenomethionine)platinum(II)
• CAS: 905854-81-1
• 化学式: C₆H₁₃Cl₂NO₂PtSe
• 分子量: 476.121
• InChiKey: SCNWAXVMESYNME-BHRFRFAJSA-L

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 selenomethionine methyl ester hydrochloride 在 NaOH 作用下， 以 水 为溶剂， 以57%的产率得到dichloro(O-methylselenomethionine)platinum(II)
  参考文献：
  名称：

  Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands

  摘要：

  The complexes dichloro[2-(phenylselanyl)ethanamine]platinum(II), dichloro[2-(benzylselanyl)ethanamine]platinum(II) and dichloro(O-methylselenomethionine)platinum(II) have been prepared and the structure of dichloro(O-methylselenomethionine)piatinum(II) has been determined by single crystal X-ray diffraction. The Pt(II) is in a square planar environment and is coordinated by two cis chloride ligands and a chelating O-methylselenomethionine ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and they are at least threefold less toxic than cisplatin in both cell lines. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.03.008