{PPN}{HS} | 119435-49-3

• 英文名称: {PPN}{HS}
• CAS: 119435-49-3
• 化学式: C₃₆H₃₀NP₂*HS
• 分子量: 571.662
• InChiKey: HKXBLLDXOAINCO-UHFFFAOYSA-M

反应信息

• 作为反应物：
  描述：

  (MeSPh)Fe(CO)4 、 {PPN}{HS} 以 乙腈 为溶剂， 以80%的产率得到{PPN}{HSFe(CO)4}
  参考文献：
  名称：

  Thiolate, thioether, and thiol derivatives of iron(0) carbonyls

  摘要：

  DOI：

  10.1021/ja00192a016
• 作为产物：
  描述：

  双(三苯基正膦基)氯化铵 在 sodium hydrogensulfide 作用下， 以 乙腈 为溶剂， 以95 %的产率得到{PPN}{HS}
  参考文献：
  名称：

  Chemoselective Proteomics, Zinc Fingers, and a Zinc(II) Model for H2S Mediated Persulfidation

  摘要：

  The gasotransmitter hydrogen sulfide (H2S) is thought to be involved in the post‐translational modification of cysteine residues to produce reactive persulfides. A persulfide‐specific chemoselective proteomics approach with mammalian cells has identified a broad range of zinc finger (ZF) proteins as targets of persulfidation. Parallel studies with isolated ZFs show that persulfidation is mediated by ZnII, O2, and H2S, with intermediates involving oxygen‐ and sulfur‐based radicals detected by mass spectrometry and optical spectroscopies. A small molecule ZnII complex exhibits analogous reactivity with H2S and O2, giving a persulfidated product. These data show that ZnII is not just a biological structural element, but also plays a critical role in mediating H2S‐dependent persulfidation. ZF persulfidation appears to be a general post‐translational modification and a possible conduit for H2S signaling. This work has implications for our understanding of H2S‐mediated signaling and the regulation of ZFs in cellular physiology and development.

  DOI：

  10.1002/anie.202401003