| 143362-01-0

• CAS: 143362-01-0
• 化学式: C₂₀H₃₄B₂₀N₂O₄
• 分子量: 582.721
• InChiKey: BLIGPVMKSTXITJ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  3-{4-(1,2-dicarba-closo-dodecaboran(12)-1-ylmethoxy)phenyl}-5-(2-(2-{2-(2-nitroimidazol-1-yl)ethoxy}ethoxy)methyl)isoxazole 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Tumour-targetted boranes. Part 2. Coupling of closo-carboranes to substituted 2-nitroimidazoles via 1,3-dipolar cycloaddition

  摘要：

  Carboranes targetted to specific tumour tissues are important for boron neutron capture therapy of cancer. Direct syntheses of carboranes linked to 2-nitroimidazole were unsuccessful. A mild procedure for 1,3-dipolar cycloaddition of 4-(carboranylmethoxy)benzonitrile N-oxide 32 with a nitroimidazolyl-alkene 27 and with nitroimidazolyl-alkynes 3 and 30 has been developed. using a series of model reactions, yielding a dihydroisoxazole 28 and the isoxazoles 29 and31. respectively. The nitrile oxide 32 is unusually stable. Dithioacetals are shown to be suitable protecting groups for aromatic aldehydes under the vigorous reductive and Lewis acidic-basic conditions,of carborane formation. 6-Methoxy-4H-[1]benzopyrano[4,3-c]isoxazole 16 been synthesised by intramolecular 1,3-dipolar cycloaddition. The structure of-the isoxazole derivative 29 has been confirmed by an X-ray crystal structure analysis.

  DOI：

  10.1039/p19940000203