[RuCl(η⁶-1-isopropyl-4-methylbenzene)(1,10-phenanthroline-5,6-dione)][hexafluorophosphate] | 1361334-43-1

• 英文名称: [RuCl(η⁶-1-isopropyl-4-methylbenzene)(1,10-phenanthroline-5,6-dione)][hexafluorophosphate]
• 英文别名: [(η⁶-p-cymene)Ru(1,10-phenantroline-5,6-dione)Cl](PF₆)；[RuCl(η⁶-p-cym)(1,10-phenanthroline-5,6-dione)][PF₆]；[(η⁶-p-cymene)Ru(1,10-phenanthroline-5,6-dione)Cl][PF6]；[(η⁶-p-cymene)Ru(phendione)Cl](PF₆)
• CAS: 1361334-43-1
• 化学式: C₂₂H₂₀ClN₂O₂Ru*F₆P
• 分子量: 625.9
• InChiKey: DGPBBGKERDVSEV-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  六氟磷酸银 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1,10-邻二氮杂菲-5,6-二酮 生成 [RuCl(η⁶-1-isopropyl-4-methylbenzene)(1,10-phenanthroline-5,6-dione)][hexafluorophosphate]
  参考文献：
  名称：

  钌 1,10-菲咯啉-5,6-二酮芳烃配合物的体外和体内生物活性

  摘要：

  钌 (II) 芳烃配合物具有良好的化学治疗特性。在这项研究中，通过分析两种 Ru(II)对甲基异丙基苯衍生物与 1,10-phenanthroline-5,6-dione 配体的生物效应，评估了 Ru(II) 络合物中抗衡阴离子的作用-分子式 [(η 6 -arene)Ru(L)Cl][X] X = CF 3 SO 3 (JHOR10) and PF 6(JHOR11)。JHOR10 和 JHOR11 的生物活性在卵巢癌细胞系 A2780、结直肠癌细胞系 HCT116、多柔比星抗性 HCT116 (HCT116-Dox) 和正常人真皮成纤维细胞中进行了检测。JHOR10 和 JHOR11 两种复合物均显示出对 A2780 和 HCT116 细胞系的抗增殖作用，以及对成纤维细胞的低细胞毒性。有趣的是，JHOR11 在 HCT116-Dox 癌细胞系中也显示出抗增殖活性，而 JHOR10 则没有活性。对

  DOI：

  10.3390/ijms232113594

文献信息

• Synthesis of Ruthenium Tris‐Diimine Photosensitizers Substituted by Four Methylphosphonate Anchoring Groups for Dye‐Sensitized Photoelectrochemical Cell Applications
  作者：Nicolas Queyriaux、Emmanouil Giannoudis、Jean‐François Lefebvre、Vincent Artero、Murielle Chavarot‐Kerlidou

  DOI：10.1002/ejic.201900151

  日期：2019.4.24

  The design and synthesis of ruthenium tris‐diimine photosensitizers appropriately functionalized to be (i) anchored onto transparent conductive oxides (TCO) and (ii) covalently coupled with a water‐splitting catalyst represents an important target for solar fuel production in dye‐sensitized photoelectrochemical cells (DS‐PECs). In this study, two different synthetic routes to prepare heteroleptic [Ru(4

  适当地功能化为（i）固定在透明导电氧化物（TCO）上和（ii）与水分解催化剂共价偶联的钌三二亚胺光敏剂的设计与合成代表了染料敏化光电化学中太阳能燃料生产的重要目标单元（DS-PEC）。在这项研究中，评估了两种不同的制备杂合[Ru（4,4'-（CH 2 PO 3 Et 2）2 -bpy）2（N ^ N）]（PF 6）2配合物的合成途径，范围和包括半夹心η有机金属途径的限制6芳烃钌络合物作为合成中间体正在得到专门研究。报道了根据第三二亚胺N ^ N配体的性质而变化的一系列新颖结构的光谱学和电化学表征。
• Antitumor and antiparasitic activity of novel ruthenium compounds with polycyclic aromatic ligands
  作者：Helena Guiset Miserachs、Micaella Cipriani、Jordi Grau、Marta Vilaseca、Julia Lorenzo、Andrea Medeiros、Marcelo A. Comini、Dinorah Gambino、Lucía Otero、Virtudes Moreno

  DOI：10.1016/j.jinorgbio.2015.06.007

  日期：2015.9

  Five novel ruthenium(II) arene complexes with polycyclic aromatic ligands were synthesized, comprising three compounds of the formula [RuCl(eta(6)-p-cym)(L)][PF6], where p-cym = 1-isopropyl-4-methylbenzene and Late the bidentate aromatic ligands 1,10-phenanthroline-5,6-dione, 1, 5-amine-1,10-phenanthroline, 4, or 5,6-epoxy-5,6-dihydro-phenanthroline, 5. In the other two complexes [RuCl2(eta(6)-p-cym)(L')], the metal is coordinated to a monodentate ligand L', where L' is phenanthridine, 2, or 9-carbonylanthracene, 3. All compounds were fully characterized by mass spectrometry and elemental analysis, as well as NMR and IR spectroscopic techniques. Obtained ruthenium compounds as well as their respective ligands were tested for their antiparasitic and antitumoral activities. Even though all compounds showed lower Trypanosoma brucei activity than the free ligands, they also resulted less toxic on mammalian cells. Cytotoxicity assays on HL60 cells showed a moderate antitumoral activity for all ruthenium compounds. Compound 1 was the most potent antitumoral (IC50 = 1.26 +/- 0.78 mu M) and antiparasitic (IC50 = 0.19 +/- 0.05 mu M) agent, showing high selectivity towards the parasites (selectivity index >100). As complex I was the most promising antitumoral compound, its interaction with ubiquitin as potential target was also studied. In addition, obtained ruthenium compounds were found to bind DNA, and they are thought to interact with this macromolecule mainly through intercalation of the aromatic ligand. (C) 2015 Elsevier Inc. All rights reserved.