[2-((2,6-dimethylphenyl)amino)-2-oxo-1-(2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepin-3-yl)ethyl]ferrocene | 1370658-65-3

• 英文名称: [2-((2,6-dimethylphenyl)amino)-2-oxo-1-(2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepin-3-yl)ethyl]ferrocene
• 英文别名: N-(2,6-dimethylphenyl)-2-ferrocenyl-2-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)acetamide
• CAS: 1370658-65-3
• 化学式: C₂₉H₂₇FeN₃O₃
• 分子量: 521.399
• InChiKey: RTJJYTSYCMIFPZ-TXEPZDRESA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2,2-dimethyl-5-ferrocenylmethylene-1,3-dioxane-4,6-dione 、 2,6-二甲基苯基异腈 、 邻苯二胺 在 水 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以67%的产率得到[2-((2,6-dimethylphenyl)amino)-2-oxo-1-(2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepin-3-yl)ethyl]ferrocene
  参考文献：
  名称：

  Synthesis of New Tetrahydro-1,5-benzodiazepin-3-yl-2-phenylacetamidesviaIsocyanide-Based Multicomponent Reactions

  摘要：

  New tetrahydro‐1H‐1,5‐benzodiazepin‐2‐phenylacetamides were synthesized in good yields by a four‐component reaction of benzylidene Meldrum's acid, benzene‐1,2‐diamines, isocyanides, and water in CH2Cl2 at room temperature.

  DOI：

  10.1002/jhet.1041

文献信息

• Isocyanide-Based Five-Component Synthesis of 2-Aryl-2-(2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepin-3-yl)acetamides (=α-Aryl-2,3,4,5-tetrahydro-2,4-dioxo-1H-1,5-benzodiazepine-3-acetamides)
  作者：Roya Akbarzadeh、Tayebeh Amanpour、Ali Abolhasani Soorki、Ayoob Bazgir

  DOI：10.1002/hlca.201100313

  日期：2012.3

  AbstractAn efficient and simple method for the synthesis of new 2‐aryl‐2‐(2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepin‐3‐yl)acetamides (=α‐aryl‐2,3,4,5‐tetrahydro‐2,4‐dioxo‐1H‐1,5‐benzodiazepine‐3‐acetamides) by a five‐component condensation reaction of benzene‐1,2‐diamine (1), Meldrum's acid (2), aldehydes 3, isocyanides 4, and H2O in CH2Cl2 at room temperature is reported (Table 1 and Scheme 2). These products were evaluated in vitro for their antibacterial activities (Table 2).