[Pt(IV)Cl4(2,2'-biimidazole)] | 861395-14-4

• 英文名称: [Pt(IV)Cl4(2,2'-biimidazole)]
• 英文别名: [Pt(IV)Cl4(H2bim)]
• CAS: 861395-14-4
• 化学式: C₆H₆Cl₄N₄Pt
• 分子量: 471.032
• InChiKey: LFBQIDACODFMAM-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  联咪唑 、 sodium hexachloroplatinate(IV) hexahydrate 以 水 为溶剂， 以48%的产率得到[Pt(IV)Cl4(2,2'-biimidazole)]
  参考文献：
  名称：

  Synthesis and cytotoxicity of new Pt(IV) complexes of 2,2′-biimidazole and derivatives

  摘要：

  Compounds of type [PtCl4(LL)] [LL = 2,2'-biimidazole (H(2)bim); N-methyl-2,2'-biimidazole (MeHbim); N-hydroxyethyl-2,2'-biimidazole (HOEtHbim); or N,N'-dimethyl-2,2'-biimidazole (Me(2)bim)] were prepared and characterized. The structure of [PtCl4(Me(2)bim)] was determined by X-ray diffractometry. The crystal consists of discrete [PtCl4(Me(2)bim)] units in which the Pt atom is coordinated to the four Cl atoms and to the unmethylated N atoms in a distorted octahedral environment. Spectroscopic data suggest that all the other complexes have similar structures. The complexes of H(2)bim, MeHbim and Me(2)bim showed cytotoxic activity against both human ovarian carcinoma A2780 and the corresponding cisplatin-resistant line, A2780cis. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2005.04.008