| 79018-48-7

• CAS: 79018-48-7；97718-60-0
• 化学式: C₁₈H₂₄Cl₂N₂Pd₂
• 分子量: 552.148
• InChiKey: FHBQFTRWVZFAFX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  5-diphenylphosphanyl-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetra-pentylresorcin[4]arene 、 以 二氯甲烷 为溶剂， 反应 0.5h， 以93%的产率得到chlorido(o-dimethylaminomethylphenyl-C,N)[5-diphenylphosphanyl-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arene]palladium(II)
  参考文献：
  名称：

  Resorcinarenyl‐Phosphines in Suzuki–Miyaura Cross‐Coupling Reactions of Aryl Chlorides

  摘要：

  AbstractTwo phosphines built on a bowl‐shaped resorcin[4]arene skeleton, namely 5‐diphenylphosphanyl‐ and 5‐diisopropylphosphanyl‐4(24),6(10),12(16),18(22)‐tetramethylenedioxy‐2,8,14,20‐tetrapentylresorcin[4]arene, have been synthesised and tested in the Suzuki–Miyaura cross‐coupling reaction of aryl halides. Combining these ligands with [Pd(OAc)2] resulted in highly active catalysts that allowed the formation of o,o′‐biphenyls starting from aryl chlorides. The remarkable activities observed possibly arise from 1) the capacity of the phosphines to operate transiently as P,O chelators, thereby increasing the electron density of the metal, and 2) the ability of the ligands to embed metal–organic units, which, when occurring, makes the ligand considerably bulkier so as to disfavour the coordination of a second phosphine. Both features are known to facilitate the oxidative addition step.

  DOI：

  10.1002/ejic.201301473