4-(4-methoxyphenyl)-N'-(2-methylphenyl)-4-oxobutanohydrazide | 912963-67-8

• 英文名称: 4-(4-methoxyphenyl)-N'-(2-methylphenyl)-4-oxobutanohydrazide
• 英文别名: 4-(4-methoxyphenyl)-N'-(2-methylphenyl)-4-oxobutanehydrazide
• CAS: 912963-67-8
• 化学式: C₁₈H₂₀N₂O₃
• 分子量: 312.368
• InChiKey: NBQYFAVEXHSHKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Acylhydrazine P2X7 antagonists and uses thereof
  申请人：Nelson W. Derek

  公开号：US20060276505A1

  公开（公告）日：2006-12-07

  The present invention discloses a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein D, A, m, n, R x and R y are defined in the description. The present invention also relates to pharmaceutical compositions of compounds of formula (I), which are useful for treating a disorder selected from the group consisting of chronic inflammatory pain, neuropathic pain, inflammation, neurodegeneration, depression and promoting neuroregeneration. The present invention also relates to a method for treating pain, neuropathic pain, inflammation, chronic inflammatory pain, neurodegeneration, depression and promoting neuroregeneration in a mammal using compounds of formula (II), a pharmaceutically acceptable salt, ester, amide or prodrug thereof, wherein R 3 and R 4 are defined in the description.

  本发明揭示了一种式（I）的化合物或其药学上可接受的盐或前药，其中D，A，m，n，Rx和Ry在说明中定义。本发明还涉及式（I）化合物的药物组合物，其用于治疗选择自慢性炎性疼痛、神经病理性疼痛、炎症、神经退行性疾病、抑郁症和促进神经再生的疾病。本发明还涉及一种使用式（II）化合物、其药学上可接受的盐、酯、酰胺或前药治疗哺乳动物的疼痛、神经病理性疼痛、炎症、慢性炎性疼痛、神经退行性疾病、抑郁症和促进神经再生的方法，其中R3和R4在说明中定义。