4-(N-(2-chloro-4-fluorobenzyl)-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid | 1254205-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(N-(2-chloro-4-fluorobenzyl)-N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)sulfamoyl)benzoic acid
• 英文别名: 4-[(2-Chloro-4-fluorophenyl)methyl-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfamoyl]benzoic acid
• CAS: 1254205-77-0
• 化学式: C₂₀H₁₂Cl₂F₄N₂O₄S
• 分子量: 523.292
• InChiKey: UVOJKAWFTGIVRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  96
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS<br/>[FR] DÉRIVÉS D'ACIDE SULFAMOYL BENZOÏQUE EN TANT QU'ANTAGONISTES DE TRPM8
  申请人：RAQUALIA PHARMA INC

  公开号：WO2010125831A1

  公开（公告）日：2010-11-04

  The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.

  本发明涉及化合物的磺胺基苯甲酸衍生物（I）或其药学上可接受的盐，其制备方法，含有它们的药物组合物以及它们在治疗通过TRPM8受体介导的各种疾病中的用途。
• SULFAMOYL BENZOIC ACID DERIVATIVES AS TRPM8 ANTAGONISTS
  申请人：Inoue Tadashi

  公开号：US20120094964A1

  公开（公告）日：2012-04-19

  The present invention relates to sulfamoyl benzoic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the TRPM8 receptor.

  本发明涉及公式（I）的磺酰苯甲酸衍生物或其药学上可接受的盐，其制备过程，含有它们的制药组合物以及它们在治疗通过TRPM8受体介导的各种疾病中的应用。