N-[4-(1-cyclobutylpiperidin-4-yloxy)phenyl]-2-(pyrrolidin-1-yl)acetamide | 1394808-42-4

• 英文名称: N-[4-(1-cyclobutylpiperidin-4-yloxy)phenyl]-2-(pyrrolidin-1-yl)acetamide
• 英文别名: N-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-pyrrolidin-1-ylacetamide
• CAS: 1394808-42-4
• 化学式: C₂₁H₃₁N₃O₂
• 分子量: 357.496
• InChiKey: IJOROPGNWRQUIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  44.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS<br/>[FR] NOUVEAUX COMPOSÉS UTILISÉS EN TANT QUE LIGANDS DES RÉCEPTEURS H3 HISTAMINIQUES
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2012114348A1

  公开（公告）日：2012-08-30

  The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors.

  本发明涉及公式（I）的新化合物，以及它们的药用盐和含有它们的组合物。本发明还涉及一种制备上述新化合物及其药用盐的方法。公式（I）的化合物在治疗与组胺H3受体相关的各种疾病方面是有用的。
• NOVEL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS
  申请人：Nirogi Ramakrishna

  公开号：US20140135304A1

  公开（公告）日：2014-05-15

  The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H 3 receptors.

  本发明涉及式(I)的新化合物，以及它们的药用盐和含有它们的组合物。本发明还涉及一种制备上述新化合物及其药用盐的方法。式(I)的化合物在治疗与组胺H3受体相关的各种疾病中是有用的。
• US9079888B2
  申请人：——

  公开号：US9079888B2

  公开（公告）日：2015-07-14