| 1401071-26-8

• CAS: 1401071-26-8
• 化学式: C₂₅H₂₇Cl₂N₂PRu
• 分子量: 558.453
• InChiKey: GMWQXQXUNGFZLX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 1H-咪唑-2-基(二苯基)膦 以 二氯甲烷 为溶剂， 反应 24.0h， 以28%的产率得到
  参考文献：
  名称：

  Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands

  摘要：

  A series of p-cymene ruthenium(II) complexes with imidazol-2-yl phosphines as PN ligands was prepared. Depending on the number of imidazolyl substituents in the ligands Ph3-nP(im)(n) {1-3: n = 1-3, im imidazol-2-yl (a), 1-methylimidazol-2-yl (b)} different coordination modes were observed: kappa P, kappa N-2,N or kappa N-3,N,N. The complexes were tested for their cytotoxicity in different cancer cell lines. Most of the compounds were found to be non-toxic; The compounds [(p-cymene)Ru(1a)Cl-2] (4a) shows cytotoxicity towards A2780sens and Hct116 cells in the mM range but not in H4IIE cells. The cytotoxicity is decreased upon introduction of a methyl group as [(p-cymene)Ru(1b)Cl-2] (4b) shows only modest toxicities in the cell lines investigated. The kappa P compound [(p-cymene)Ru(2a)Cl-2] (5a) shows selective toxicity in H4IIE cells after 72 h whereas the kappa N-2, N compound [(p-cymene)Ru(2a) Cl] OTf (5a') showed no toxicity in the cell lines investigated which again. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2012.06.027