花生四烯酸钠 | 6610-25-9

• 物质功能分类: 分析化学 - 食品安全 - 脂肪酸、脂肪酸甲酯
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 花生四烯酸钠
• 中文别名: 花生四烯酸钠盐
• 英文名称: Arachidonic acid sodium salt
• CAS: 6610-25-9
• 化学式: C20H32NaO2
• 分子量: 327.5
• InChiKey: RMBLTWUTZAFABA-XVSDJDOKSA-N

物化性质

• 闪点：
  113℃
• 溶解度：
  在甲醇中可溶50 mg/mL，澄清，无色至淡黄色

计算性质

• 辛醇/水分配系数(LogP)：
  5.84
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险类别码：
  R19
• WGK Germany：
  3
• 危险品运输编号：
  NONH for all modes of transport

文献信息

• Use of amtolmetin guacyl for the production of a drug for counteracting blood platelet aggregation
  申请人：Medosan Ricerca S.r.l.

  公开号：EP1709963A2

  公开（公告）日：2006-10-11

  The present invention relates to the use of amtolmetin guacyl for the production of an anti-inflammatory drug for counteracting blood platelet aggregation. Furthermore, the uses of amtolmetin guacyl for the treatment of thrombophlebitis, as anti-platelet agent and for anti-inflammatory and antalgic treatment, particularly in the case of infarcted subjects and of subjects suffering from an ictus of thrombotic type are disclosed.

  本发明涉及使用amtolmetin guacyl生产抗血小板聚集的消炎药。此外，本发明还公开了氨甲苯酸愈创木酚在治疗血栓性静脉炎、抗血小板药物、抗炎和抗焦虑治疗方面的用途，特别是在治疗梗塞患者和血栓性静脉炎患者方面的用途。
• LIPOSOMES FOR THE TREATMENT OF OCULAR DISEASES
  申请人：TDC Technology Dedicated to Care S.r.l.

  公开号：EP3603621A1

  公开（公告）日：2020-02-05

  The invention refers to a product made of liposomes which comprises lactoferrin and a component selected from hyaluronic acid or chitosan, as active ingredients, as well as to compositions comprising it and their use in the prevention and/or treatment of diseases related to the eye, such as for example the ocular diseases characterized by the presence of an inflammatory condition.

  本发明涉及一种脂质体产品，其中包含乳铁蛋白和一种选自透明质酸或壳聚糖的成分作为活性成分，还涉及包含乳铁蛋白的组合物及其在预防和/或治疗与眼睛有关的疾病（例如以存在炎症条件为特征的眼部疾病）中的用途。
• Emulsion formulations of an NK-1 receptor antagonist and uses thereof
  申请人：Heron Therapeutics, Inc.

  公开号：US10624850B2

  公开（公告）日：2020-04-21

  Disclosed herein are novel pharmaceutical formulations of a neurokinin-1 (NK-1) receptor antagonist suitable for parenteral administration including intravenous administration. Also included are formulations including both the NK-1 receptor antagonist and dexamethasone sodium phosphate. The pharmaceutical formulations are stable oil-in-water emulsions for non-oral treatment of emesis and are particularly useful for treatment of subjects undergoing highly emetogenic cancer chemotherapy.

  本文公开了一种神经激肽-1（NK-1）受体拮抗剂的新型药物制剂，适合肠外给药，包括静脉给药。还包括同时含有 NK-1 受体拮抗剂和地塞米松磷酸钠的制剂。这些药物制剂是稳定的水包油乳剂，用于非口服治疗呕吐，尤其适用于治疗正在接受高致呕吐癌症化疗的患者。
• Liposomes for the treatment of ocular diseases
  申请人：TDC Technology Dedicated to Care srl

  公开号：US10835494B2

  公开（公告）日：2020-11-17

  The invention refers to a product made of liposomes which comprises lactoferrin and a component selected from hyaluronic acid or chitosan, as active ingredients, as well as to compositions comprising it and their use in the prevention and/or treatment of diseases related to the eye, such as for example the ocular diseases characterized by the presence of an inflammatory condition.

  本发明涉及一种脂质体产品，其中包含乳铁蛋白和一种选自透明质酸或壳聚糖的成分作为活性成分，还涉及包含乳铁蛋白的组合物及其在预防和/或治疗与眼睛有关的疾病（例如以存在炎症条件为特征的眼部疾病）中的用途。
• Fatty acid composition and method for fortifying nutritional products with fatty acids
  申请人：JOST CHEMICAL CO.

  公开号：US10888104B2

  公开（公告）日：2021-01-12

  A fatty acid composition is provided which can be used to make fatty acid fortified nutritional products. In one embodiment, the fatty acid composition comprises a fatty acid component, inorganic salts (which can include a phosphate salt), vitamins, and optionally a protein source and optionally a carbohydrate source. The composition can further include additional nutrients and combinations thereof. In another embodiment, the fatty acid composition is only the fatty acid (i.e., consists of a sodium or potassium fatty acid) which is spray dried. In both embodiments, the fatty acid composition is not microencapsulated in a waxy or carbohydrate substrate, yet the powdered composition is flowable and is easily dispersible in a liquid to form a stable dispersion in the liquid by stirring or shaking the powder in the liquid for only a short period of time.

  本发明提供了一种脂肪酸组合物，可用于制造脂肪酸强化营养产品。在一个实施方案中，脂肪酸组合物包括脂肪酸成分、无机盐（可包括磷酸盐）、维生素、可选的蛋白质来源和可选的碳水化合物来源。该组合物还可以包括其他营养成分及其组合。在另一个实施方案中，脂肪酸组合物仅是经过喷雾干燥的脂肪酸（即由脂肪酸钠或脂肪酸钾组成）。在这两个实施方案中，脂肪酸组合物没有被微囊化在蜡质或碳水化合物基质中，但粉末状组合物是可流动的，很容易分散在液体中，只需在液体中短时间搅拌或摇动粉末，就能在液体中形成稳定的分散体。